Relationship between serum IL-7 concentrations and lymphopenia upon different levels of HIV immune control

被引：16

作者：

Fluur, Caroline ^{[1
]}

Rethi, Bence

Thang, Pham Hong

Vivar, Nancy

Mowafi, Frida

Lopalco, Lucia

Foppa, Caterina Uberti

Karlsson, Anders

Tambussi, Giuseppe

Chiodi, Francesca

机构：

[1] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden

[2] Natl Inst Hyg & Epidemiol, HIV AIDS Dept, Hanoi, Vietnam

[3] Ist Sci San Raffaele, Infect Dis Clin, I-20132 Milan, Italy

[4] Karolinska Univ Hosp, Dept Infect Dis, Stockholm, Sweden

来源：

AIDS | 2007年 / 21卷 / 08期

关键词：

D O I：

10.1097/QAD.0b013e32810c8caa

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Serum IL-7 levels correlate with T-cell depletion in HIV-infected individuals. In some patients, we observed that serum IL-7 decreases upon progression to AIDS, suggesting a role for IL-7 in T-cell maintenance in sporadic cases. Interestingly, IL-7 levels were significantly lower in stable longterm non-progressors (LTNP) than in patients who lost the LTNP status in a 3-year follow-up (P < 0.001), indicating that the serum IL-7 concentration might be a valuable marker for maintenance of the LTNP state.

引用

页码：1048 / 1050

页数：3

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