Vomeronasal organ detects odorants in absence of signaling through main olfactory epithelium

被引:167
作者
Trinh, K
Storm, DR
机构
[1] Univ Washington, Program Mol & Cellular Biol, Seattle, WA 98195 USA
[2] Univ Washington, Dept Pharmacol, Seattle, WA 98195 USA
关键词
D O I
10.1038/nn1039
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
It is commonly assumed that odorants are detected by the main olfactory epithelium (MOE) and pheromones are sensed through the vomeronasal organ (VNO). The complete loss of MOE-mediated olfaction in type-3 adenylyl cyclase knockout mice (AC3(-/-)) allowed us to examine chemosensory functions of the VNO in the absence of signaling through the MOE. Here we report that AC3(-/-) mice are able to detect certain volatile odorants via the VNO. These same odorants elicited electro-olfactogram transients in the VNO and MOE of wild-type mice, but only VNO responses in AC3(-/-) mice. This indicates that some odorants are detected through an AC3-independent pathway in the VNO.
引用
收藏
页码:519 / 525
页数:7
相关论文
共 48 条
[1]  
Amoore J E, 1970, MOL BASIS ODOR, P28
[2]   IDENTIFICATION OF A SPECIALIZED ADENYLYL CYCLASE THAT MAY MEDIATE ODORANT DETECTION [J].
BAKALYAR, HA ;
REED, RR .
SCIENCE, 1990, 250 (4986) :1403-1406
[3]   ADULT NARIS CLOSURE PROFOUNDLY REDUCES TYROSINE-HYDROXYLASE EXPRESSION IN MOUSE OLFACTORY-BULB [J].
BAKER, H ;
MOREL, K ;
STONE, DM ;
MARUNIAK, JA .
BRAIN RESEARCH, 1993, 614 (1-2) :109-116
[4]   Mice deficient in Golf are anosmic [J].
Belluscio, L ;
Gold, GH ;
Nemes, A ;
Axel, R .
NEURON, 1998, 20 (01) :69-81
[5]   Evidence for distinct signaling mechanisms in two mammalian olfactory sense organs [J].
Berghard, A ;
Buck, LB ;
Liman, ER .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (06) :2365-2369
[6]  
Berghard A, 1996, J NEUROSCI, V16, P909
[7]   RAPID KINETICS OF 2ND MESSENGER FORMATION IN OLFACTORY TRANSDUCTION [J].
BREER, H ;
BOEKHOFF, I ;
TAREILUS, E .
NATURE, 1990, 345 (6270) :65-68
[8]   Odorant and pheromone binding by aphrodisin, a hamster aphrodisiac protein [J].
Briand, L ;
Huet, JC ;
Perez, V ;
Lenoir, C ;
Nespoulous, C ;
Boucher, Y ;
Trotier, D ;
Pernollet, JC .
FEBS LETTERS, 2000, 476 (03) :179-185
[9]   THE MAJOR HISTOCOMPATIBILITY COMPLEX AND THE CHEMOSENSORY RECOGNITION OF INDIVIDUALITY IN RATS [J].
BROWN, RE ;
SINGH, PB ;
ROSER, B .
PHYSIOLOGY & BEHAVIOR, 1987, 40 (01) :65-73
[10]   General anosmia caused by a targeted disruption of the mouse olfactory cyclic nucleotide-gated cation channel [J].
Brunet, LJ ;
Gold, GH ;
Ngai, J .
NEURON, 1996, 17 (04) :681-693