Protective avian influenza in ovo vaccination with non-replicating human adenovirus vector

被引：70

作者：

Toro, Haroldo

Tang, De-chu C.

Suarez, David L.

Sylte, Matt J.

Pfeiffer, Jennifer

Van Kampen, Kent R. ^{[1
]}

机构：

[1] Vaxin Inc, Birmingham, AL 35211 USA

[2] Auburn Univ, Dept Pathobiol, Auburn, AL 36849 USA

[3] USDA ARS, SE Poultry Res Lab, Athens, GA 30605 USA

来源：

VACCINE | 2007年 / 25卷 / 15期

关键词：

avian influenza; in ovo vaccination; RCA-free adenovirus vector; DIVA;

D O I：

10.1016/j.vaccine.2006.09.047

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Protective immunity against avian influenza virus was elicited in chickens by single-dose in ovo vaccination with a non-replicating human adenovirus vector encoding an H5N9 avian influenza virus hemagglutinin. Vaccinated chickens were protected against both H5N1 (89% hemagglutinin homology; 68% protection) and H5N2 (94% hemagglutinin homology; 100% protection) highly pathogenic avian influenza virus challenges. This vaccine can be mass-administered using available robotic in ovo injectors which provide a major advantage over current vaccination regimens. In addition, this class of adenovirus-vectored vaccines can be produced rapidly with improved safety since they do not contain any replication-competent adenoviruses. Furthermore, this mode of vaccination is compatible with epidemiological surveys of natural avian influenza virus infections. (c) 2006 Elsevier Ltd. All rights reserved.

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收藏

页码：2886 / 2891

页数：6

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