Efficient stereoselective synthesis of cis,syn-hydroxyitraconazole isomers

被引：4

作者：

Tanoury, GJ

Senanayake, CH

Hett, R

Hong, YP

Wald, SA

机构：

[1] Dept. of Chem. R. and D., Sepracor Inc., Marlborough, MA 01752

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 45期

关键词：

D O I：

10.1016/S0040-4039(97)10129-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first stereoselective synthesis of cis,syn-hydroxyitraconazole isomers via a tricomponent coupling strategy is described. The isomers are prepared from two chiral subunits and connected via an achiral linker. A highly stereoselective route to the cis,syn-isomers is presented. (C) 1997 Elsevier Science Ltd.

引用

页码：7839 / 7842

页数：4

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