Functional expression of Cre recombinase in sub-regions of mouse CNS and retina

被引：13

作者：

Eriksson, B ^{[1
]}

Bergqvist, I ^{[1
]}

Eriksson, M ^{[1
]}

Holmberg, D ^{[1
]}

机构：

[1] Umea Univ, Dept Cell & Mol Biol, S-90187 Umea, Sweden

来源：

FEBS LETTERS | 2000年 / 479卷 / 03期

关键词：

embryonic development; transgenic mouse; hippocampus; ganglion;

D O I：

10.1016/S0014-5793(00)01893-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We describe a strategy for generating CNS and retina sub-region-specific mutations using the Cre/loxP system. Transgenic mice expressing Cre recombinase under the control of the c-kit promoter were established. Functional Cre expression was predominantly found to be restricted to the CA1, CA2 and CA3 regions of the hippocampus, the anterior region of the dentate gyrus, and to the ganglion cell layer of the retina. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：106 / 110

页数：5

共 25 条

[1]

ANDRE C, 1989, ONCOGENE, V4, P1047

[2] Transgenic Cre recombinase expression in germ cells and early embryogenesis directs homogeneous and ubiquitous deletion of loxP-flanked gene segments [J].

Bergqvist, I ;

Eriksson, B ;

Eriksson, M ;

Holmberg, D .

FEBS LETTERS, 1998, 438 (1-2) :76-80

[3] Bypass of lethality with mosaic mice generated by Cre-loxP-mediated recombination [J].

Betz, UAK ;

Vosshenrich, CAJ ;

Rajewsky, K ;

Muller, W .

CURRENT BIOLOGY, 1996, 6 (10) :1307-1316

[4] DEATH BEFORE BIRTH - CLUES FROM GENE KNOCKOUTS AND MUTATIONS [J].

COPP, AJ .

TRENDS IN GENETICS, 1995, 11 (03) :87-93

[5] The Eph family in retinal axon guidance [J].

Drescher, U ;

Bonhoeffer, F ;

Muller, BK .

CURRENT OPINION IN NEUROBIOLOGY, 1997, 7 (01) :75-80

[6]

Franklin K B J, 2008, MOUSE BRAIN STEREOTA

[7] DELETION OF A DNA-POLYMERASE-BETA GENE SEGMENT IN T-CELLS USING CELL-TYPE-SPECIFIC GENE TARGETING [J].

GU, H ;

MARTH, JD ;

ORBAN, PC ;

MOSSMANN, H ;

RAJEWSKY, K .

SCIENCE, 1994, 265 (5168) :103-106

[8] INDUCIBLE GENE TARGETING IN MICE [J].

KUHN, R ;

SCHWENK, F ;

AGUET, M ;

RAJEWSKY, K .

SCIENCE, 1995, 269 (5229) :1427-1429

[9] TARGETED ONCOGENE ACTIVATION BY SITE-SPECIFIC RECOMBINATION IN TRANSGENIC MICE [J].

LAKSO, M ;

SAUER, B ;

MOSINGER, B ;

LEE, EJ ;

MANNING, RW ;

YU, SH ;

MULDER, KL ;

WESTPHAL, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (14) :6232-6236

[10]

LAVIGNE MT, 1996, SCIENCE, V274, P1123

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