Sheathless electrospray ionization interfaces for capillary electrophoresis-mass spectrometric detection - Advantages and limitations

被引：56

作者：

Issaq, HJ ^{[1
]}

Janini, GM ^{[1
]}

Chan, KC ^{[1
]}

Veenstra, TD ^{[1
]}

机构：

[1] NCI, SAIC Frederick Inc, Lab Proteom & Analyt Technol, Frederick, MD 20702 USA

来源：

JOURNAL OF CHROMATOGRAPHY A | 2004年 / 1053卷 / 1-2期

关键词：

CE/ESI-MS; CE interface; sheathless CE interfaces; CE/MS;

D O I：

10.1016/j.chroma.2004.08.116

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A review of sheathless interfaces for capillary electrophoresis (CE)-mass spectrometry (MS) is presented. The review discusses the on-line CE-MS system requirements, advantages and weaknesses of current sheathless interface designs for CE-electrospray ionization MS, and comparison between sheath flow and sheathless interfaces. The advantages and limitations of three sheathless designs are discussed and commented upon, these include single-capillary, two-capillary and three-piece designs. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：37 / 42

页数：6

共 39 条

[1]

Barnidge DR, 1999, RAPID COMMUN MASS SP, V13, P994, DOI 10.1002/(SICI)1097-0231(19990615)13:11<994::AID-RCM596>3.0.CO

[2]

2-W

[3]

Barroso MB, 1999, J AM SOC MASS SPECTR, V10, P1271

[4]

Bateman KP, 1997, RAPID COMMUN MASS SP, V11, P307

[5] CAPILLARY ELECTROPHORESIS MASS-SPECTROMETRY [J].

CAI, JY ;

HENION, J .

JOURNAL OF CHROMATOGRAPHY A, 1995, 703 (1-2) :667-692

[6] A novel sheathless interface for capillary electrophoresis/electrospray ionization mass spectrometry using an in-capillary electrode [J].

Cao, P ;

Moini, M .

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 1997, 8 (05) :561-564

[7] Sheathless capillary electrophoresis/electrospray mass spectrometry using a carbon-coated fused silica capillary [J].

Chang, YZ ;

Her, GR .

ANALYTICAL CHEMISTRY, 2000, 72 (03) :626-630

[8]

DING J, 1999, ANAL CHEM, V71

[9] ONLINE TIME-OF-FLIGHT MASS-SPECTROMETRIC ANALYSIS OF PEPTIDES SEPARATED BY CAPILLARY ELECTROPHORESIS [J].

FANG, LL ;

ZHANG, R ;

WILLIAMS, ER ;

ZARE, RN .

ANALYTICAL CHEMISTRY, 1994, 66 (21) :3696-3701

[10] Protein identification by capillary zone electrophoresis/microelectrospray ionization-tandem mass spectrometry at the subfemtomole level [J].

Figeys, D ;

vanOostveen, I ;

Ducret, A ;

Aebersold, R .

ANALYTICAL CHEMISTRY, 1996, 68 (11) :1822-1828

← 1 2 3 4 →