Stage of breast cancer at diagnosis among women with cosmetic breast implants

被引:21
作者
Hölmich, LR
Mellemkjær, L
Gunnarsdóttir, K
Tange, UB
Krag, C
Moller, S
McLaughlin, JK
Olsen, JH
机构
[1] Danish Canc Soc, Inst Canc Epidemiol, DK-2100 Copenhagen, Denmark
[2] Rigshosp, DBCG Secretariat, Danish Breast Canc Cooperat Grp, DK-2100 Copenhagen, Denmark
[3] Univ Copenhagen Hosp, Rigshosp, Dept Oncol, DK-2100 Copenhagen, Denmark
[4] Univ Copenhagen, Herlev Hosp, Dept Plast Surg, DK-2730 Herlev, Denmark
[5] Int Epidemiol Inst, Rockville, MD 20850 USA
[6] Vanderbilt Univ, Med Ctr, Vanderbilt Ingram Comprehens Canc Ctr, Dept Med, Nashville, TN 37240 USA
关键词
augmentation; breast cancer; breast implants; breast cancer diagnosis; breast neoplasms; silicone;
D O I
10.1038/sj.bjc.6600819
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Concern has been raised about the potential delay in breast cancer diagnosis in the augmented breast. We linked a cohort of 2955 women, who received cosmetic breast implants in Denmark during the period 1973-1997 with the Danish Cancer Registry and the Danish Breast Cancer Cooperative Group register. We identified 23 incident cases of invasive breast cancer diagnosed subsequent to breast implantation. We randomly selected I I controls for each case from the Danish Breast Cancer Cooperative Group's register, and obtained detailed information on all study subjects about surgery, histopathology and stage of breast cancer at diagnosis, intended adjuvant treatment according to trial protocols and overall survival. We found that women with breast implants on average were diagnosed with breast cancer at the same stage as controls. Significantly more women with breast implants had tumour cells in the surgical margins according to the Danish Breast Cancer Cooperative Group's data. There was no significant difference in overall survival between the two groups after an average of 6.4 years of follow-up. Based on this limited number of women with breast cancer subsequent to breast augmentation, breast implants do not appear to delay the diagnosis of breast cancer, and no evidence of impaired survival after breast cancer diagnosis in augmented women was found. (C) 2003 Cancer Research UK.
引用
收藏
页码:832 / 838
页数:7
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