Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence

被引:426
作者
Cantorna, MT [1 ]
Mahon, BD [1 ]
机构
[1] Penn State Univ, Dept Nutr Sci, University Pk, PA 16802 USA
关键词
vitamin D; autoimmunity; multiple sclerosis; arthritis; inflammatory bowel disease; insulin-dependent diabetes mellitus;
D O I
10.1177/153537020422901108
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Low vitamin D status has been implicated in the etiology of autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, insulin-dependent diabetes mellitus, and inflammatory bowel disease. The optimal level of vitamin D intake required to support optimal immune function is not known but is likely to be at least that required for healthy bones. Experimentally, vitamin D deficiency results in the increased incidence of autoimmune disease. Mechanistically, the data point to a role for vitamin D in the development of self-tolerance. The vitamin D hormone (1,25-dihydroxy vitamin D-3) regulates T helper cell (Th1) and dendritic cell function while inducing regulatory T-cell function. The net result is a decrease in the Th1-driven autoimmune response and decreased severity of symptoms. This review discusses the accumulating evidence pointing to a link between vitamin D and autoimmunity. Increased vitamin D intakes might decrease the incidence and severity of autoimmune diseases and the rate of bone fracture.
引用
收藏
页码:1136 / 1142
页数:7
相关论文
共 62 条
[1]  
Andjelkovic Z, 1999, CLIN EXP RHEUMATOL, V17, P453
[2]  
Andreassen H, 1998, SCAND J GASTROENTERO, V33, P1087
[3]   Inflammatory bowel disease and osteoporosis [J].
Andreassen, H ;
Rungby, J ;
Dahlerup, JF ;
Mosekilde, L .
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1997, 32 (12) :1247-1255
[4]  
ASLAN A, 1992, AM J GASTROENTEROL, V87, P432
[5]  
Auer DP, 2000, ANN NEUROL, V47, P276, DOI 10.1002/1531-8249(200002)47:2<276::AID-ANA28>3.0.CO
[6]  
2-1
[7]   SEASONAL-VARIATION OF MULTIPLE-SCLEROSIS EXACERBATIONS IN ARIZONA [J].
BAMFORD, CR ;
SIBLEY, WA ;
THIES, C .
NEUROLOGY, 1983, 33 (06) :697-701
[8]   In vitro generation of interleukin 10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines [J].
Barrat, FJ ;
Cua, DJ ;
Boonstra, A ;
Richards, DF ;
Crain, C ;
Savelkoul, HF ;
de Waal-Malefyt, R ;
Coffman, RL ;
Hawrylowicz, CM ;
O'Garra, A .
JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (05) :603-616
[9]   1,25-dihydroxyvitamin D3 inhibits dendritic cell differentiation and maturation in vitro [J].
Berer, A ;
Stöckl, J ;
Majdic, O ;
Wagner, T ;
Kollars, M ;
Lechner, K ;
Geissler, K ;
Oehler, L .
EXPERIMENTAL HEMATOLOGY, 2000, 28 (05) :575-583
[10]   Transforming growth factor β1 (TGFβ1) mRNA level correlates with magnetic resonance imaging disease activity in Multiple Sclerosis patients [J].
Bertolotto, A ;
Capobianco, M ;
Malucchi, S ;
Manzardo, E ;
Audano, L ;
Bergui, M ;
Bradac, GB ;
Mutani, R .
NEUROSCIENCE LETTERS, 1999, 263 (01) :21-24