Age-related differences in the expression of receptors for TGF-β in human osteoblast-like cells in vitro

被引：7

作者：

Bätge, B

Feydt, A

Gebken, J

Klein, H

Notbohm, H

Müller, PK

Brinckmann, J

机构：

[1] Klinikum Neustadt, D-23730 Neustadt, Germany

[2] Med Univ Lubeck, Inst Med Mol Biol, Lubeck, Germany

[3] Med Univ Lubeck, Dermatol Klin, Lubeck, Germany

[4] Med Univ Lubeck, Med Klin 1, Lubeck, Germany

来源：

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES | 2000年 / 108卷 / 04期

关键词：

TGF-beta; receptor; osteoblast; ageing;

D O I：

10.1055/s-2000-8001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The cell surface expression of receptors for TGF-beta was studied in human osteoblasts derived from femoral trabecular bone of a total of 19 patients aged 2-83 years. All cell populations investigated showed a similar profile of expression of TGF-beta receptors (T beta R) I, II and III (betaglycan). There were no significant differences in cell differentiation or proliferative behaviour between the age groups. The TGF-P receptor number per cell significantly increased with age, while the receptor affinity tended to decrease. IGF-I did not influence T beta R expression in vitro. The results indicate an age-dependent and IGF-I independent increase of osteoblastic TGF-beta receptors in human osteoblastlike cells in vitro.

引用

收藏

页码：311 / 315

页数：5

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