Polarized epithelial membrane traffic: conservation and plasticity

被引：235

作者：

Mostov, K ^{[1
]}

Su, T ^{[1
]}

ter Beest, M ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA

来源：

NATURE CELL BIOLOGY | 2003年 / 5卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/ncb0403-287

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Most cells are polarized and have distinct plasma membrane domains, which are the result of polarized trafficking of proteins and lipids. Great progress has been made in elucidating the highly conserved polarized targeting machinery. A pre-eminent challenge now is to understand the plasticity of polarized traffic, how it is altered by differentiation and dedifferentiation during development, as well as the adaptation of differentiated cells to meet changing physiological needs.

引用

页码：287 / 293

页数：7

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