The 4C technique:: the 'Rosetta stone' for genome biology in 3D?

被引：20

作者：

Ohlsson, Rolf ^{[1
]}

Gondor, Anita ^{[1
]}

机构：

[1] Uppsala Univ, Evolut Biol Ctr, Dept Genet & Dev, S-75236 Uppsala, Sweden

来源：

CURRENT OPINION IN CELL BIOLOGY | 2007年 / 19卷 / 03期

关键词：

D O I：

10.1016/j.ceb.2007.04.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Despite considerable efforts, the spatial link between the nuclear architecture and the genome remains enigmatic. The 4C method, independently innovated in four different laboratories, might in combination with other methods change that. As this method is based on the unbiased identification of sequences interacting with specific baits, there are unique opportunities for unravelling the secrets of how the genome functions in 3D.

引用

页码：321 / 325

页数：5

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