Keratitis caused by Scedosporium apiospermum successfully treated with a cornea transplant and voriconazole

被引:52
作者
Nulens, E
Eggink, C
Rijs, AJMM
Wesseling, P
Verweij, PE
机构
[1] Univ Nijmegen, Ctr Med, Dept Med Microbiol, NL-6500 HB Nijmegen, Netherlands
[2] Univ Nijmegen, Ctr Med, Dept Ophthalmol, NL-6500 HB Nijmegen, Netherlands
[3] Univ Nijmegen, Ctr Med, Dept Pathol, NL-6500 HB Nijmegen, Netherlands
[4] Univ Nijmegen, Ctr Infect Dis, Nijmegen, Netherlands
关键词
D O I
10.1128/JCM.41.5.2261-2264.2003
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
A case of Scedosporium apiospermum keratitis was successfully treated with oral voriconazole and penetrating keratoplasty. Voriconazole levels in the aqueous humor were 53% of the levels in plasma and exceeded the MIC for the isolate by sevenfold.
引用
收藏
页码:2261 / 2264
页数:4
相关论文
共 17 条
[1]   Severe keratomycosis secondary to Scedosporium apiospermum [J].
Díaz-Valle, D ;
del Castillo, JMB ;
Amor, E ;
Toledano, N ;
Carretero, MM ;
Díaz-Valle, T .
CORNEA, 2002, 21 (05) :516-518
[2]   Testing conditions for determination of minimum fungicidal concentrations of new and established antifungal agents for Aspergillus spp.:: NCCLS Collaborative Study [J].
Espinel-Ingroff, A ;
Fothergill, A ;
Peter, J ;
Rinaldi, MG ;
Walsh, TJ .
JOURNAL OF CLINICAL MICROBIOLOGY, 2002, 40 (09) :3204-3208
[3]   In vitro fungicidal activities of voriconazole, itraconazole, and amphotericin B against opportunistic moniliaceous and dematiaceous fungi [J].
Espinel-Ingroff, A .
JOURNAL OF CLINICAL MICROBIOLOGY, 2001, 39 (03) :954-958
[4]   Acanthamoeba keratitis associated with fungal keratitis [J].
Froumis, NA ;
Mondino, BJ ;
Glasgow, BJ .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 2001, 131 (04) :508-509
[5]   In-vitro activity of voriconazole, itraconazole and amphotericin B against filamentous fungi [J].
Johnson, EM ;
Szekely, A ;
Warnock, DW .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1998, 42 (06) :741-745
[6]   In vitro activities of new and conventional antifungal agents against clinical Scedosporium isolates [J].
Meletiadis, J ;
Meis, JFGM ;
Mouton, JW ;
Rodriquez-Tudela, JL ;
Donnelly, JP ;
Verweij, PE .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (01) :62-68
[7]   In vitro drug interaction modeling of combinations of azoles with terbinafine against clinical Scedospotium prolificans isolates [J].
Meletiadis, J ;
Mouton, JW ;
Meis, JFGM ;
Verweij, PE .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (01) :106-117
[8]  
National Committee for Clinical Laboratory Standards, 1998, M38P NAT COMM CLIN L
[9]   Pseudallescheria boydii brain abscess successfully treated with voriconazole and surgical drainage:: Case report and literature review of central nervous system pseudallescheriasis [J].
Nesky, MA ;
McDougal, EC ;
Peacock, JE .
CLINICAL INFECTIOUS DISEASES, 2000, 31 (03) :673-677
[10]   Comparison of high-performance liquid chromatographic and microbiological methods for determination of voriconazole levels in plasma [J].
Perea, S ;
Pennick, GJ ;
Modak, A ;
Fothergill, AW ;
Sutton, DA ;
Sheehan, DJ ;
Rinaldi, MG .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (05) :1209-1213