Kinin B1 receptors:: key G-protein-coupled receptors and their role in inflammatory and painful processes

被引:216
作者
Calixto, JB [1 ]
Medeiros, R [1 ]
Fernandes, ES [1 ]
Ferreira, J [1 ]
Cabrini, DA [1 ]
Campos, MM [1 ]
机构
[1] Univ Fed Santa Catarina, Ctr Biol Sci, Dept Pharmacol, BR-88049900 Florianopolis, SC, Brazil
关键词
kinins; B1; receptors; inflammation; pain; selective antagonists;
D O I
10.1038/sj.bjp.0706012
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Kinins are a family of peptides implicated in several pathophysiological events. Most of their effects are likely mediated by the activation of two G-protein-coupled receptors: B-1 and B-2. Whereas B-2 receptors are constitutive entities, B-1 receptors behave as key inducible molecules that may be upregulated under some special circumstances. In this context, several recent reports have investigated the importance of B-1 receptor activation in certain disease models. Furthermore, research on B-1 receptors in the last years has been mainly focused in determining the mechanisms and pathways involved in the process of induction. This was essentially favoured by the advances obtained in molecular biology studies, as well as in the design of selective and stable peptide and nonpeptide kinin B-1 receptor antagonists. Likewise, development of kinin B-1 receptor knockout mice greatly helped to extend the evidence about the relevance of B-1 receptors during pathological states. In the present review, we attempted to remark the main advances achieved in the last 5 years about the participation of kinin B-1 receptors in painful and inflammatory disorders. We have also aimed to point out some groups of chronic diseases, such as diabetes, arthritis, cancer or neuropathic pain, in which the strategic development of nonpeptidic oral-available and selective B-1 receptor antagonists could have a potential relevant therapeutic interest.
引用
收藏
页码:803 / 818
页数:16
相关论文
共 182 条
[1]   Early upregulation of kinin B1 receptors in retinal microvessels of the streptozotocin-diabetic rat [J].
Abdouh, M ;
Khanjari, A ;
Abdelazziz, N ;
Ongali, B ;
Couture, R ;
Hasséssian, HM .
BRITISH JOURNAL OF PHARMACOLOGY, 2003, 140 (01) :33-40
[2]   B1 receptors as a new inflammatory target.: Could this B the 1? [J].
Ahluwalia, A ;
Perretti, M .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1999, 20 (03) :100-104
[3]   Role of adapters in Toll-like receptor signalling [J].
Akira, S ;
Yamamoto, M ;
Takeda, K .
BIOCHEMICAL SOCIETY TRANSACTIONS, 2003, 31 :637-642
[4]  
Angers M, 2000, J CELL BIOCHEM, V78, P278, DOI 10.1002/(SICI)1097-4644(20000801)78:2<278::AID-JCB10>3.0.CO
[5]  
2-F
[6]   Toll-like receptor stimulation induces airway hyper-responsiveness to bradykinin, an effect mediated by JNK and NF-κB signaling pathways [J].
Bachar, O ;
Adner, M ;
Uddman, R ;
Cardell, LO .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2004, 34 (04) :1196-1207
[7]   Structure and genomic organization of the human B-1 receptor gene for kinins (BDKRB1) [J].
Bachvarov, DR ;
Hess, JF ;
Menke, JG ;
Larrivee, JF ;
Marceau, F .
GENOMICS, 1996, 33 (03) :374-381
[8]   Requirement for direct cross-talk between B1 and B2 kinin receptors for the proliferation of androgen-insensitive prostate cancer PC3 cells [J].
Barki-Harrington, L ;
Bookout, AL ;
Wang, GF ;
Lamb, ME ;
Leeb-Lundberg, LMF ;
Daaka, Y .
BIOCHEMICAL JOURNAL, 2003, 371 (02) :581-587
[9]   Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses [J].
Beg, AA .
TRENDS IN IMMUNOLOGY, 2002, 23 (11) :509-512
[10]   The role of neuropeptides and capsaicin-sensitive fibres in glutamate-induced nociception and paw oedema in mice [J].
Beirith, A ;
Santos, ARS ;
Calixto, JB .
BRAIN RESEARCH, 2003, 969 (1-2) :110-116