Proton magnetic resonance spectroscopy in Parkinson's disease and atypical parkinsonian disorders

被引：66

作者：

Federico, F ^{[1
]}

Simone, IL ^{[1
]}

Lucivero, V ^{[1
]}

Iliceto, G ^{[1
]}

DeMari, M ^{[1
]}

Giannini, P ^{[1
]}

Mezzapesa, DM ^{[1
]}

Tarantino, A ^{[1
]}

Lamberti, P ^{[1
]}

机构：

[1] UNIV BARI, INST CLIN NEUROL & NEURORADIOL, I-70124 BARI, ITALY

来源：

MOVEMENT DISORDERS | 1997年 / 12卷 / 06期

关键词：

magnetic resonance spectroscopy; Parkinson's disease; multiple-system atrophy; progressive supranuclear palsy;

D O I：

10.1002/mds.870120611

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Proton magnetic resonance spectroscopy (H-1-MRS), localized to the lentiform nucleus, was carried out in 12 patients with idiopathic Parkinson's disease (IPD), seven patients with multiple-system atrophy (MSA), seven patients with progressive supranuclear palsy (PSP), and 10 healthy age-matched controls. The study assessed the level of N-acetylaspartate (NAA), creatine-phosphocreatine (Cr), and choline (Cho) in the putamen and globus pallidus of these patients. NAA/Cho and NAA/Cr ratios were significantly reduced in MSA and PSP patients. No significant difference was found between IPD patients and controls. These results suggest an NAA deficit, due to neuronal loss, in the lentiform nucleus of MSA and PSP patients. H-1-MRS is a noninvasive technique that can provide useful information regarding striatal neuronal loss in basal ganglia of patients with atypical parkinsonian disorders and represents a potential tool for diagnosing these disorders.

引用

页码：903 / 909

页数：7

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