Using biological markers to predict risk of radiation injury

被引:94
作者
Fleckenstein, Katharina
Gauter-Fleckenstein, Benjamin
Jackson, Isabel L.
Rabbani, Zahid
Anscher, Mitchell
Vujaskovic, Zeljko
机构
[1] Duke Univ, Med Ctr, Dept Radiat Oncol, Durham, NC USA
[2] Univ Heidelberg, Mannheim Med Ctr, Dept Radiat Oncol, Mannheim, Germany
[3] Univ Heidelberg, Mannheim Med Ctr, Dept Anaesthesiol, Mannheim, Germany
[4] Virginia Commonwealth Univ, Sch Med, Dept Radiat Oncol, Richmond, VA USA
关键词
D O I
10.1016/j.semradonc.2006.11.004
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Recent advances in our understanding of the molecular events leading to the development of normal tissue complications after radiotherapy has led to an effort to identify biological markers that could identify patients at increased or decreased risk for treatment related injury. The goal of this effort is to improve the therapeutic ratio and enable physicians to optimize therapy for individual patients. In radiotherapy of the thoracic region, the lung is one of the most critical dose-limiting organs. This review briefly introduces the mechanisms of radiation-induced lung injury and gives a summary of clinical research focused on evaluating changes in biological markers before, during, and after radiation therapy of the thorax.
引用
收藏
页码:89 / 98
页数:10
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