PD-1/PD-L1 pathway and T-cell exhaustion in chronic hepatitis virus infection

被引：98

作者：

Watanabe, T. ^{[2
]}

Bertoletti, A. ^{[1
,3
,4
]}

Tanoto, T. A. ^{[3
]}

机构：

[1] ASTAR, Singapore Inst Clin Sci, Brenner Ctr Mol Med, Viral Hepatitis Lab, S-117609 Singapore, Singapore

[2] Showa Univ, Fujigaoka Hosp, Div Gastroenterol, Yokohama, Kanagawa 227, Japan

[3] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore 117595, Singapore

[4] Duke NUS Grad Med Sch, Program Emerging Viral Dis Unit, Singapore, Singapore

来源：

JOURNAL OF VIRAL HEPATITIS | 2010年 / 17卷 / 07期

关键词：

HBV; HCV; PD-1; PD-L1; T cell; CHRONIC VIRAL-INFECTION; C-VIRUS; PD-1; EXPRESSION; IMMUNE-RESPONSE; FUNCTIONAL RESTORATION; HIV-1; INFECTION; HCV INFECTION; HBV INFECTION; CD8; RESPONSES; RECEPTOR;

D O I：

10.1111/j.1365-2893.2010.01313.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Dysfunctional virus-specific T cells are a hallmark of many chronic viral infections. Recent studies have implicated the inhibitory PD-1/PD-L1 pathway with the functional impairment of T cells. In this respect, we will review the latest research on PD-1/PD-L1 pathway and T-cell exhaustion in the context of human chronic hepatitis B and C virus infections. We will also discuss the therapeutic potential of PD-1 blockade and how it may be enhanced through the modulation of other co-stimulatory/inhibitory pathways.

引用

页码：453 / 458

页数：6

共 58 条

[1] The Size of the Viral Inoculum Contributes to the Outcome of Hepatitis B Virus Infection [J].

Asabe, Shinichi ;

Wieland, Stefan F. ;

Chattopadhyay, Pratip K. ;

Roederer, Mario ;

Engle, Ronald E. ;

Purcell, Robert H. ;

Chisari, Francis V. .

JOURNAL OF VIROLOGY, 2009, 83 (19) :9652-9662

[2] Restoring function in exhausted CD8 T cells during chronic viral infection [J].

Barber, DL ;

Wherry, EJ ;

Masopust, D ;

Zhu, BG ;

Allison, JP ;

Sharpe, AH ;

Freeman, GJ ;

Ahmed, R .

NATURE, 2006, 439 (7077) :682-687

[3] The immune response during hepatitis B virus infection [J].

Bertoletti, Antonio ;

Gehring, Adam J. .

JOURNAL OF GENERAL VIROLOGY, 2006, 87 :1439-1449

[4] Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection [J].

Blackburn, Shawn D. ;

Shin, Haina ;

Haining, W. Nicholas ;

Zou, Tao ;

Workman, Creg J. ;

Polley, Antonio ;

Betts, Michael R. ;

Freeman, Gordon J. ;

Vignali, Dario A. A. ;

Wherry, E. John .

NATURE IMMUNOLOGY, 2009, 10 (01) :29-37

[5] Expression of the interleukin-7 receptor alpha chain (CD127) on virus-specific CD8+ T cells identifies functionally and phenotypically defined memory T cells during acute resolving hepatitis B virus infection [J].

Boettler, T ;

Panther, E ;

Bengsch, B ;

Nazarova, N ;

Spangenberg, HC ;

Blum, HE ;

Thimme, R .

JOURNAL OF VIROLOGY, 2006, 80 (07) :3532-3540

[6] Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection [J].

Boni, Carolina ;

Fisicaro, Paola ;

Valdatta, Caterina ;

Amadei, Barbara ;

Di Vincenzo, Paola ;

Giuberti, Tiziana ;

Laccabue, Diletta ;

Zerbini, Alessandro ;

Cavalli, Albertina ;

Missale, Gabriele ;

Bertoletti, Antonio ;

Ferrari, Carlo .

JOURNAL OF VIROLOGY, 2007, 81 (08) :4215-4225

[7] Costimulatory ligand 4-1BBL (CD137L) as an efficient adjuvant for human antiviral cytotoxic T cell responses [J].

Bukczynski, J ;

Wen, T ;

Ellefsen, K ;

Gauldie, J ;

Watts, TH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (05) :1291-1296

[8] Analysis of a successful immune response against hepatitis C virus [J].

Cooper, S ;

Erickson, AL ;

Adams, EJ ;

Kansopon, J ;

Weiner, AJ ;

Chien, DY ;

Houghton, M ;

Parham, P ;

Walker, CM .

IMMUNITY, 1999, 10 (04) :439-449

[9] Comprehensive analyses of CD8+T cell responses during longitudinal study of acute human hepatitis C [J].

Cox, AL ;

Mosbruger, T ;

Lauer, GM ;

Pardoll, D ;

Thomas, DL ;

Ray, SC .

HEPATOLOGY, 2005, 42 (01) :104-112

[10] Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection [J].

Das, Abhishek ;

Hoare, Matthew ;

Davies, Nathan ;

Lopes, A. Ross ;

Dunn, Claire ;

Kennedy, Patrick T. F. ;

Alexander, Graeme ;

Finney, Helene ;

Lawson, Alistair ;

Plunkett, Fiona J. ;

Bertoletti, Antonio ;

Akbar, Arne N. ;

Maini, Mala K. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (09) :2111-2124

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