Oxygen in acute and chronic wound healing

被引：756

作者：

Schreml, S. ^{[1
]}

Szeimies, R. M. ^{[1
]}

Prantl, L. ^{[2
]}

Karrer, S. ^{[1
]}

Landthaler, M. ^{[1
]}

Babilas, P. ^{[1
]}

机构：

[1] Univ Hosp Regensburg, Dept Dermatol, D-93042 Regensburg, Germany

[2] Univ Hosp Regensburg, Dept Plast Surg, D-93042 Regensburg, Germany

来源：

BRITISH JOURNAL OF DERMATOLOGY | 2010年 / 163卷 / 02期

关键词：

hyperbaric oxygen therapy; luminescence imaging; oxygenation; reactive oxygen species; wound oximetry; ISCHEMIA-REPERFUSION INJURY; LOWER-EXTREMITY ULCERS; GROWTH-FACTOR LEVELS; CHRONIC LEG ULCERS; HYPERBARIC-OXYGEN; OXIDATIVE STRESS; IN-VIVO; HYDROGEN-PEROXIDE; INSPIRED OXYGEN; KERATINOCYTE MIGRATION;

D O I：

10.1111/j.1365-2133.2010.09804.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100227 [皮肤病学];

摘要：

Oxygen is a prerequisite for successful wound healing due to the increased demand for reparative processes such as cell proliferation, bacterial defence, angiogenesis and collagen synthesis. Even though the role of oxygen in wound healing is not yet completely understood, many experimental and clinical observations have shown wound healing to be impaired under hypoxia. This article provides an overview on the role of oxygen in wound healing and chronic wound pathogenesis, a brief insight into systemic and topical oxygen treatment, and a discussion of the role of wound tissue oximetry. Thus, the aim is to improve the understanding of the role of oxygen in wound healing and to advance our management of wound patients.

引用

页码：257 / 268

页数：12

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