Pyridoxine as a template for the design of antiplatelet agents

被引：11

作者：

Zhang, WL

Yao, J

Pham, V

Whitney, T

Froese, D

Friesen, AD

Stang, L

Xu, C

Shuaib, A

Diakur, JM

Haque, W

机构：

[1] Canam Biores Inc, Winnipeg, MB R3T 0P4, Canada

[2] Medicure Inc, Winnipeg, MB R3T 0P4, Canada

[3] Univ Alberta Hosp, Special Coagulat Lab, Edmonton, AB T6G 2B7, Canada

[4] Univ Alberta, Dept Med, Stroke Res Lab, Edmonton, AB T6G 2B7, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 18期

关键词：

pyridoxine; antiplatelet; antiischemic;

D O I：

10.1016/j.bmcl.2004.06.079

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The B-6 vitamers have been shown to display beneficial therapeutic effects in cardiovascular related disorders. The design of novel antiplatelet agents using pyridoxine as a template has led to the discovery of a class of novel cardio- and cerebro-protective agents. The present study describes the synthesis of several of these derivatives along with the antiplatelet and antiischemic activity of derivative 16. (C) 2004 Elsevier Ltd. All rights reserved.

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收藏

页码：4747 / 4750

页数：4

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