Development and progression of diabetic retinopathy in Koreans with NIDDM

被引:38
作者
Kim, HK
Kim, CH
Kim, SW
Park, JY
Hong, SK
Yoon, YH
Lee, KU
机构
[1] Univ Ulsan, Asan Med Ctr, Coll Med, Dept Internal Med, Seoul 138600, South Korea
[2] Univ Ulsan, Asan Med Ctr, Coll Med, Dept Ophthalmol, Seoul 138600, South Korea
关键词
D O I
10.2337/diacare.21.1.134
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE - To determine the incidence and risk factors for the development and progression of diabetic retinopathy in Korean patients with NIDDM. RESEARCH DESIGN AND METHODS - A total of 186 patients with NIDDM who did not have proliferative diabetic retinopathy (PDR) at baseline were prospectively studied for 5.3 +/- 1.0 years in an outpatient clinic of a university hospital. The incidence and progression of diabetic retinopathy was determined by annual funduscopic examination by an ophthalmologist. RESULTS - Of the 130 patients who were free of diabetic retinopathy al baseline, 30 developed it, giving an incidence of 44.4/1,000 person-years. Age and known duration of diabetes, mean fasting plasma glucose, and HbA(1) levels during the follow-up period were higher in the patients who developed diabetic retinopathy. Of the 56 patients who had nonproliferative diabetic retinopathy at baseline, 11 developed PDR, giving an incidence of 37.5/1,000 person-years. The patients who progressed to PDR during follow-up (progressors) had a higher change of BMI and urinary albumin excretion rate at baseline and a higher mean HbA(1) during the follow-up period than the nonprogressors. Cox proportional hazards analysis revealed that mean HbA(1) was the only independent risk factor for both the development and progression of diabetic retinopathy. CONCLUSIONS - The incidence of PDR in Korean NIDDM patients is comparable to that reported in other populations. Poor glycemic control is the most important risk factor for both the development and progression of diabetic retinopathy in NIDDM patients.
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页码:134 / 138
页数:5
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