Synthesis and evaluation of modified oligodeoxynucleotides containing diphosphodiester internucleotide linkages

被引：18

作者：

Ahmadibeni, Yousef ^{[1
]}

Parang, Keykavous ^{[1
]}

机构：

[1] Univ Rhode Isl, Dept Biomed & Pharmaceut Sci, Kingston, RI 02881 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 25期

关键词：

CD spectropolarinnetry; diphosphodiesters; nucleotides; solid-phase synthesis; thermal analysis;

D O I：

10.1002/anie.200605029

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Build a bridge: Oligodeoxynucleotides (ODNs) containing diphosphodiester bridges were synthesized by a solid-phase synthesis strategy. Modified ODNs formed stable duplexes with complementary modified and unmodified nucleic acid sequences. The modified oligomers were resistant to degradation by DNase I and 3′-exonuclease I under conditions in which unmodified ODNs were degraded. B = T, A, G, or C. (Chemical Equation Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4739 / 4743

页数：5

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