Regulation of cap-dependent translation by eIF4E inhibitory proteins

被引：768

作者：

Richter, JD ^{[1
]}

Sonenberg, N

机构：

[1] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA

[2] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada

[3] McGill Univ, McGill Canc Ctr, Montreal, PQ H3G 1Y6, Canada

来源：

NATURE | 2005年 / 433卷 / 7025期

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

D O I：

10.1038/nature03205

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Eukaryotic messenger RNAs contain a modified guanosine, termed a cap, at their 50 ends. Translation of mRNAs requires the binding of an initiation factor, eIF4E, to the cap structure. Here, we describe a family of proteins that through a shared sequence regulate cap-dependent translation. The biological importance of this translational regulation is immense, and affects such processes as cell growth, development, oncogenic transformation and perhaps even axon pathfinding and memory consolidation.

引用

页码：477 / 480

页数：4

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