Resolution of primary severe acute respiratory syndrome-associated coronavirus infection requires Stat1

被引：111

作者：

Hogan, RJ

Cao, GP

Rowe, T

Bell, P

Flieder, D

Paragas, J

Kobinger, GP

Wivel, NA

Crystal, RG

Boyer, J

Feldmann, H

Voss, TG

Wilson, JM

机构：

[1] So Res Inst, Dept Homeland Secur, Birmingham, AL 35255 USA

[2] Univ Penn, Dept Med, Div Med Genet, Gene Therapy Program, Philadelphia, PA 19104 USA

[3] Cornell Univ, Weill Med Coll, Dept Pathol, New York, NY USA

[4] Cornell Univ, Weill Med Coll, Dept Med Genet, New York, NY USA

[5] USA, Med Res Inst Infect Dis, Frederick, MD USA

[6] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB, Canada

[7] Natl Microbiol Lab, Winnipeg, MB, Canada

来源：

JOURNAL OF VIROLOGY | 2004年 / 78卷 / 20期

关键词：

D O I：

10.1128/JVI.78.20.11416-11421.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Intranasal inhalation of the severe acute respiratory syndrome coronavirus (SARS CoV) in the immunocompetent mouse strain 129SvEv resulted in infection of conducting airway epithelial cells followed by rapid clearance of virus from the lungs and the development of self-limited bronchiolitis. Animals resistant to the effects of interferons by virtue of a deficiency in Stat1 demonstrated a markedly different course following intranasal inhalation of SARS CoV, one characterized by replication of virus in lungs and progressively worsening pulmonary disease with inflammation of small airways and alveoli and systemic spread of the virus to livers and spleens.

引用

页码：11416 / 11421

页数：6

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