Tumorigenesis in the brain: Location, location, location

被引：53

作者：

Gilbertson, Richard J.

Gutmann, David H.

机构：

[1] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

[2] St Jude Childrens Res Hosp, Dept Dev Neurobiol, Memphis, TN 38105 USA

[3] St Jude Childrens Res Hosp, Dept Oncol, Memphis, TN 38105 USA

来源：

CANCER RESEARCH | 2007年 / 67卷 / 12期

关键词：

RADIAL GLIA; STEM-CELLS; NEUROFIBROMATOSIS; PROGENITORS;

D O I：

10.1158/0008-5472.CAN-07-0760

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Emerging evidence from numerous laboratories supports the notion that brain tumors arise from cells with stem cell/ neuroglial progenitor cell properties ("cancer stem cells"). Two recent studies suggest that histologically similar tumors from different brain regions are molecularly distinct because they arise from distinct populations of site-restricted progenitor cells. These new findings imply an interaction between the cell of origin, the tumor microenvironment, and specific cancer-causing genetic changes in the evolution of central nervous system tumors.

引用

收藏

页码：5579 / 5582

页数：4

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