Targeting ncRNAs by plant secondary metabolites: The ncRNAs game in the balance towards malignancy inhibition

被引：22

作者：

Gulei, Diana ^{[1
]}

Mehterov, Nikolay ^{[2
,3
,4
]}

Nabavi, Seyed Mohammad ^{[5
]}

Atanasov, Atanas Georgiev ^{[6
,7
,8
]}

Berindan-Neagoe, Ioana ^{[1
,9
,10
]}

机构：

[1] Iuliu Hatieganu Univ Med & Pharm, MEDFUTURE Res Ctr Adv Med, 23 Marinescu St, Cluj Napoca 400337, Romania

[2] Med Univ Plovdiv, Dept Med Biol, Fac Med, 15-A Vassil Aprilov Blvd, Plovdiv 4000, Bulgaria

[3] Technol Ctr Emergency Med, 15-A Vassil Aprilov Blvd, Plovdiv 4000, Bulgaria

[4] Ctr Plant Syst Biol & Biotechnol, Ruski Blvd 139, Plovdiv 4000, Bulgaria

[5] Baqiyatallah Univ Med Sci, Appl Biotechnol Res Ctr, Tehran, Iran

[6] Polish Acad Sci, Inst Genet & Anim Breeding, Postepu 36A, PL-05552 Jastrzebiec, Magdalenka, Poland

[7] Univ Vienna, Dept Pharmacognosy, Fac Life Sci, Althanstr 14, A-1090 Vienna, Austria

[8] Med Univ Vienna, Inst Vasc Biol & Thrombosis Res, Ctr Physiol & Pharmacol, Vienna, Austria

[9] Iuliu Hatieganu Univ Med & Pharm, Res Ctr Funct Genom Biomed & Translat Med, 23 Marinescu St, Cluj Napoca 400337, Romania

[10] Oncol Inst Prof Dr Ion Chiricuta, Dept Funct Genom & Expt Pathol, Republ 34 St, Cluj Napoca 400015, Romania

来源：

BIOTECHNOLOGY ADVANCES | 2018年 / 36卷 / 06期

关键词：

Phytochemicals; Polyphenols; miRNAs; ncRNAs; Natural products; MDR; Cancer; GREEN TEA POLYPHENOL; ACID PHENETHYL ESTER; OVERCOME MULTIDRUG-RESISTANCE; COA REDUCTASE INHIBITORS; GRAPE SEED EXTRACT; CANCER CELL-GROWTH; NF-KAPPA-B; NATURAL-PRODUCTS; OXIDATIVE STRESS; DOWN-REGULATION;

D O I：

10.1016/j.biotechadv.2017.11.003

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

current trend of combining state of the art technologies with quondam treatments in order to overcome existing gaps in the clinical area determined an increased interest into polyphenols, common dietary phytochemicals, for the prevention and treatment of chronic diseases, especially cancer. The reemergence of poly phenols in the cancer field is sustained by advanced-omits technologies able to identify coding and non-coding genes and their related signaling pathways modulated by natural compounds. Identification of the structural correspondence between interacting molecules will allow the development of more targeted and informed therapeutic strategies for cancer management.

引用

页码：1779 / 1799

页数：21

共 181 条

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