Synthesis of an isomer of the oxaspirobicyclic tetronic acid unit of the CCK-B receptor antagonist tetronothiodin

被引：29

作者：

Page, PCB ^{[1
]}

Vahedi, H

Batchelor, KJ

Hindley, SJ

Edgar, M

Beswick, P

机构：

[1] Univ Loughborough, Dept Chem, Loughborough LE11 3TU, Leics, England

[2] GlaxoSmithKline, Med Res Ctr, Dept Med Chem, Neurol & GI Ctr Excellence Drug Discovery, Stevenage SG2 2NY, Herts, England

来源：

SYNLETT | 2003年 / 07期

关键词：

tetronothiodin; Diels-Alder; Dieckmann; spiro tetronic acid; CCK;

D O I：

10.1055/s-2003-39287

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An isomer of the oxaspirobicyclic tetronic acid unit of the CCK-B Receptor antagonist tetronothiodin, diastereoisomeric at the spiro centre, has been synthesized in five steps from dienol 4.

引用

页码：1022 / 1024

页数：3

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