Regioselective Dieckmann cyclisations leading to enantiopure highly functionalised tetramic acid derivatives

被引：72

作者：

Andrews, MD

Brewster, AG

Crapnell, KM

Ibbett, AJ

Jones, T

Moloney, MG

Prout, K

Watkin, D

机构：

[1] Univ Oxford, Dyson Perrins Lab, Dept Chem, Oxford OX1 3QY, England

[2] Univ Oxford, Chem Crystallog Lab, Oxford OX1 3PD, England

[3] Zeneca Pharmaceut, Macclesfield SK10 4TG, Cheshire, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1998年 / 02期

关键词：

D O I：

10.1039/a706014i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Regioselective Dieckmann cyclisations using an N-acyloxazolidine derived from L-serine give substituted tetramic adds in high yield and enantioselectivity, The products are easily deprotected under mild conditions to give hydroxymethyltetramic acids.

引用

页码：223 / 235

页数：13

共 59 条

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