Protective effect of caffeine against neurodegeneration in a model of Parkinson's disease in rat: behavioral and histochemical evidence

被引：49

作者：

Joghataie, MT

Roghani, M

Negahdar, F

Hashemi, L

机构：

[1] Shaded Univ, Sch Med, Dept Physiol, Tehran 141557435, Iran

[2] Iran Univ Med Sci, Sch Med, Dept Anat, Tehran, Iran

来源：

PARKINSONISM & RELATED DISORDERS | 2004年 / 10卷 / 08期

关键词：

caffeine; 6-hydroxydopamine; Parkinson's disease; rat;

D O I：

10.1016/j.parkreldis.2004.06.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Epidemiological studies have consistently demonstrated an inverse association between coffee consumption and Parkinson's disease (PD). This study was designed to investigate the beneficial effect of caffeine at a dose comparable to that of human exposure in a model of PD. For this purpose, unilateral intrastriatal 6-hydroxydopamine (6-OHDA)-lesioned rats were pretreated with caffeine (20 mg/kg; i.p.) 1 h before surgery and treated twice a day (10 mg/kg) for 1 month. Apomorphine-induced rotations and number of Nissl-stained neurons of substantia nigra pars compacta (SNC) were counted. The results demonstrated that caffeine administration for 1 month could attenuate the rotational behavior in lesioned rats and protect the neurons of SNC against 6-OHDA toxicity. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：465 / 468

页数：4

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