The impact of chronic carrier of hepatitis B virus on liver function in a 7-day ultramarathon race

被引:6
作者
Chou, Shang-Lin [1 ]
Chou, Ming-Yueh [2 ,3 ]
Wang, Yu-Hsuan [4 ]
Kuo, Fon-Chu [5 ]
Kao, Wei-Fong [6 ,7 ]
机构
[1] Fooyin Univ Hosp, Dept Emergency Med, Pingtung, Taiwan
[2] Kaohsiung Vet Gen Hosp, Ctr Geriatr & Gerontol, Kaohsiung, Taiwan
[3] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan
[4] Kaohsiung Med Univ, Chung Ho Mem Hosp, Dept Nursing, Kaohsiung, Taiwan
[5] Soochow Univ, Dept Comp Sci & Informat Management, Taipei, Taiwan
[6] Taipei Med Univ Hosp, Dept Emergency & Crit Care Med, 252 Wu Hsing St, Taipei 110, Taiwan
[7] Taipei Med Univ, Sch Med, Dept Emergency Med, Coll Med, Taipei, Taiwan
关键词
hepatitis B virus (HBV); liver function; 7-day races; ultramarathon; ULTRA-MARATHON; EXERCISE; RUNNERS; PARAMETERS; MARKERS; DISEASE; RISK; RUN;
D O I
10.1016/j.jcma.2015.10.006
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
Background: Several changes in physiological characteristics occur during long-distance and 24-hour ultramarathons, including hyponatremia, skeletal muscle breakdown, plasma volume changes, iron depletion, anemia, and possible hepatic damage. The purpose of this study was to investigate the impact of hepatitis B virus (HBV) carrier status on liver function during multi-day races. Methods: This prospective study recruited 10 Taiwanese runners who were scheduled to participate in the 7-day 2008 Athens Ultramarathon Festival Race, and three of them were chronic carriers of HBV. Blood samples were collected before, during, and 3 days after the race, including alkaline phosphatase (ALP), albumin (ALB), total protein (TP) levels, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin (T-BIL) Results: Ten Taiwanese runners (40% female; average age 52.3 +/- 7.9 years) who all planned to run in the race were recruited. Three runners were chronic carriers of HBV (HBV carrier), and all participants were anti-HCV antibody-negative and anti-hepatitis A virus (HAV) IgG-positive. There were no significant time-by-group effects on ALP, ALB, and TP levels, but the change over time effects were significant (p < 0.001, p = 0.001 and p = 0.010, respectively). ALT, AST, and T-BIL increased significantly to markedly higher levels in the HBV carrier group compared to the non-carrier group (group effect p = 0.009, p = 0.004, and p = 0.05, respectively), and the time-by-group interaction was also significant for these liver function markers (p < 0.001, p < 0.001, and p = 0.001, respectively). Conclusion: Compared to their counterparts, runners who are HBV carriers had significantly greater increases in levels of ALT, AST, and T-BIL during a 7-day ultramarathon, indicating that the liver function of carriers is more highly impacted in these races. Copyright (C) 2016, the Chinese Medical Association. Published by Elsevier Taiwan LLC.
引用
收藏
页码:179 / 184
页数:6
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