Effects of reward anticipation, reward presentation, and spatial parameters on the firing of single neurons recorded in the subiculum and nucleus accumbens of freely moving rats

被引:57
作者
Martin, PD
Ono, T
机构
[1] Coll France, LPPA, CNRS, F-75231 Paris 05, France
[2] Toyama Med & Pharmaceut Univ, Fac Med, Dept Physiol, Sugitani, Toyama 93001, Japan
关键词
subiculum; accumbens; striatum; medial forebrain bundle; information content; spatial; directional; running speed;
D O I
10.1016/S0166-4328(00)00249-7
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The subiculum is the major output of the hippocampal formation (involved in spatial processing). Subicular afferents innervate the nucleus accumbens, which is thought to integrate limbic reward information with motor output. Rats were chronically implanted with extra-cellular recording electrodes aimed at both structures to investigate the functional relationship between them. Animals were then trained on a spatial task in which they searched for random locations where they would receive rewarding medial forebrain bundle stimulation. At random times a cue tone was sounded, indicating that the reward location was in the center of the environment. Rats quickly learned to run to the center upon hearing the tone in order to receive a reward. Simultaneously recorded groups of up to eight subicular and accumbens neurons were found to display alterations in firing rate after rewarding medial forebrain bundle stimulation. Moreover, neurons in both subiculum and accumbens displayed alterations in firing rate prior to arrival at the center during cued runs, i.e. they anticipated predictable rewards. Subicular and accumbens firing was also correlated with spatial location. However, neurons in accumbens were more likely to respond to task events, and these responses were more varied, than those seen in subiculum. Thus, while convergence of spatial and reward information occurs at the level of single cells in both subiculum and nucleus accumbens, these structures also display functional localization. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:23 / 38
页数:16
相关论文
共 44 条
[1]   THE CROSSED MESOSTRIATAL PROJECTION - NEUROCHEMISTRY AND DEVELOPMENTAL RESPONSE TO LESION [J].
ALTAR, A ;
NEVE, KA ;
LOUGHLIN, SE ;
MARSHALL, JF ;
FALLON, JH .
BRAIN RESEARCH, 1983, 279 (1-2) :1-8
[2]  
[Anonymous], 1977, DRIVES REINFORCEMENT
[3]  
BARNES CA, 1990, PROG BRAIN RES, V83, P287
[4]   SIMULATION OF SPATIAL-LEARNING IN THE MORRIS WATER MAZE BY A NEURAL-NETWORK MODEL OF THE HIPPOCAMPAL-FORMATION AND NUCLEUS-ACCUMBENS [J].
BROWN, MA ;
SHARP, PE .
HIPPOCAMPUS, 1995, 5 (03) :171-188
[5]   Robotic and neuronal simulation of the hippocampus and rat navigation [J].
Burgess, N ;
Donnett, JG ;
Jeffery, KJ ;
OKeefe, J .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1997, 352 (1360) :1535-1543
[6]   A MODEL OF HIPPOCAMPAL FUNCTION [J].
BURGESS, N ;
RECCE, M ;
OKEEFE, J .
NEURAL NETWORKS, 1994, 7 (6-7) :1065-1081
[7]   NEURONAL FIRING IN THE NUCLEUS-ACCUMBENS IS ASSOCIATED WITH THE LEVEL OF CORTICAL AROUSAL [J].
CALLAWAY, CW ;
HENRIKSEN, SJ .
NEUROSCIENCE, 1992, 51 (03) :547-553
[8]   FIRING PATTERNS OF NUCLEUS-ACCUMBENS NEURONS DURING COCAINE SELF-ADMINISTRATION IN RATS [J].
CARELLI, RM ;
KING, VC ;
HAMPSON, RE ;
DEADWYLER, SA .
BRAIN RESEARCH, 1993, 626 (1-2) :14-22
[9]   A FUNCTIONAL LINK BETWEEN THE LIMBIC CORTEX AND VENTRAL STRIATUM - PHYSIOLOGY OF THE SUBICULUM ACCUMBENS PATHWAY [J].
DASILVA, FHL ;
ARNOLS, DEAT ;
NEIJT, HC .
EXPERIMENTAL BRAIN RESEARCH, 1984, 55 (02) :205-214
[10]   THE CROSSED NIGROSTRIATAL PROJECTION DECUSSATES IN THE VENTRAL TEGMENTAL DECUSSATION [J].
DOUGLAS, R ;
KELLAWAY, L ;
MINTZ, M ;
VANWAGENINGEN, G .
BRAIN RESEARCH, 1987, 418 (01) :111-121