TOR Complexes and the Maintenance of Cellular Homeostasis

被引：171

作者：

Eltschinger, Sandra ^{[1
,2
]}

Loewith, Robbie ^{[1
,2
,3
]}

机构：

[1] Univ Geneva, Dept Mol Biol, CH-1211 Geneva, Switzerland

[2] iGE3 Inst Genet & Genom Geneva, Geneva, Switzerland

[3] Natl Ctr Competence Res Chem Biol, Geneva, Switzerland

来源：

TRENDS IN CELL BIOLOGY | 2016年 / 26卷 / 02期

基金：

瑞士国家科学基金会; 欧洲研究理事会;

关键词：

REGULATES ACTIN POLARIZATION; AMINO-ACID LEVELS; SACCHAROMYCES-CEREVISIAE; RAG GTPASES; PHOSPHOPROTEOME REVEALS; SPHINGOLIPID SYNTHESIS; SIGNALING PATHWAY; PROTEIN-KINASES; GROWTH-CONTROL; PHOSPHOLIPID ASYMMETRY;

D O I：

10.1016/j.tcb.2015.10.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The Target of Rapamycin (TOR) is a conserved serine/threonine (ser/thr) kinase that functions in two, distinct, multiprotein complexes called TORC1 and TORC2. Each complex regulates different aspects of eukaryote growth: TORC1 regulates cell volume and/or mass by influencing protein synthesis and turnover, while TORC2, as detailed in this review, regulates cell surface area by influencing lipid production and intracellular turgor. TOR complexes function in feedback loops, implying that downstream effectors are also likely to be involved in upstream regulation. In this regard, the notion that TORCs function primarily as mediators of cellular and organismal homeostasis is fundamentally different from the current, predominate view of TOR as a direct transducer of extracellular biotic and abiotic signals.

引用

收藏

页码：148 / 159

页数：12

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