Hydrogen bonding in salicylsalicylic acid (salsalate) crystals

被引：11

作者：

Cox, PJ ^{[1
]}

Gilmour, GI ^{[1
]}

MacManus, SM ^{[1
]}

机构：

[1] Robert Gordon Univ, Sch Pharm, Aberdeen AB10 1FR, Scotland

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2000年 / 204卷 / 1-2期

关键词：

salsalate; X-ray crystallography; hydrogen bonding; crystals;

D O I：

10.1016/S0378-5173(00)00495-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

An X-ray crystallographic study of the drug salicylsalicylic acid (salsalate) has been performed. Crystal formation of the drug is influenced by both inter- and intra-molecular hydrogen bonding. in addition an OH group in salsalate can occupy alternate ortho positions resulting in two hydrogen bonding motifs within a single crystal. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：133 / 136

页数：4

共 18 条

[1] SIR92 - a program for automatic solution of crystal structures by direct methods [J].

ALTOMARE, A ;

CASCARANO, G ;

GIACOVAZZO, G ;

GUAGLIARDI, A ;

BURLA, MC ;

POLIDORI, G ;

CAMALLI, M .

JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1994, 27 :435-435

[2] ASSESSMENT OF SALSALATE, A NONACETYLATED SALICYLATE, IN THE TREATMENT OF PATIENTS WITH ARTHRITIS [J].

ATKINSON, MH ;

MENARD, HA ;

KALISH, GH .

CLINICAL THERAPEUTICS, 1995, 17 (05) :827-837

[3] PATTERNS IN HYDROGEN BONDING - FUNCTIONALITY AND GRAPH SET ANALYSIS IN CRYSTALS [J].

BERNSTEIN, J ;

DAVIS, RE ;

SHIMONI, L ;

CHANG, NL .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1995, 34 (15) :1555-1573

[4] THE QUANTITATIVE-DETERMINATION OF ASPIRIN AND ITS DEGRADATION PRODUCTS IN A MODEL SOLUTION AEROSOL [J].

BLONDINO, FE ;

BYRON, PR .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1995, 13 (02) :111-119

[5] Solid-state NMR investigations on the nature of hydrogen bonds [J].

Brunner, E ;

Sternberg, U .

PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY, 1998, 32 :21-57

[6] Hydrogen bonds and a hydrogen-bonded chain in Mannich bases of 5,5'-dinitro-2,2'-biphenol-FT-IR and H-1 NMR studies [J].

Brzezinski, B ;

Urjasz, H ;

Bartl, F ;

Zundel, G .

JOURNAL OF MOLECULAR STRUCTURE, 1997, 435 (01) :59-64

[7] X-RAY AND MOLECULAR MECHANICS STUDIES ON THE SESQUITERPENE LACTONE EUPATOCUNIN-O-BROMOBENZOATE - AN UNUSUAL CASE OF DISORDER INVOLVING ATROPISOMERISM [J].

COX, PJ .

JOURNAL OF CRYSTALLOGRAPHIC AND SPECTROSCOPIC RESEARCH, 1993, 23 (03) :203-208

[8]

DZIEMBOWSKA T, 1994, POL J CHEM, V68, P1455

[9]

Lommerse JPM, 1997, J COMPUT CHEM, V18, P757, DOI 10.1002/(SICI)1096-987X(19970430)18:6<757::AID-JCC3>3.0.CO

[10]

2-R

← 1 2 →