Pharmacogenetics in reproductive and perinatal medicine

被引：12

作者：

Alfirevic, Ana ^{[1
]}

Alfirevic, Zarko ^{[2
]}

Pirmohamed, Munir ^{[1
]}

机构：

[1] Univ Liverpool, Dept Pharmacol & Therapeut, Liverpool L69 3GE, Merseyside, England

[2] Liverpool Womens Hosp, Liverpool, Merseyside, England

来源：

PHARMACOGENOMICS | 2010年 / 11卷 / 01期

关键词：

obstetrics; perinatal; pharmacogenetics; polymorphisms; reproduction; NEURAL-TUBE DEFECTS; DIHYDROFOLATE-REDUCTASE DHFR; STIMULATING-HORMONE RECEPTOR; INFLAMMATORY-BOWEL-DISEASE; STEVENS-JOHNSON-SYNDROME; ONE-CARBON METABOLISM; FACTOR-V-LEIDEN; BREAST-CANCER; FOLIC-ACID; BETA-2-ADRENERGIC RECEPTOR;

D O I：

10.2217/PGS.09.153

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The clinical application of pharmacogenetics has been well accepted by some medical specialties, but not all. The aim of this review is to discuss the current use of pharmacogenetics in reproductive and perinatal medicine and to highlight areas where pharmacogenetics may be able to help in the future to predict response to medicines in terms of efficacy and safety. This applies to drugs that are specific to pregnancy and reproduction, as well as drugs prescribed for the treatment of medical disorders in pregnancy. Our review points out the need for well-designed clinical studies on the efficacy and safety of medicines used in women of childbearing age in order to define the additional utility provided by pharmacogenetic testing.

引用

页码：65 / 79

页数：15

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