Incorporation of carbohydrates and peptides into large triazine-based screening libraries using automated parallel synthesis

被引：65

作者：

Gustafson, GR ^{[1
]}

Baldino, CM ^{[1
]}

O'Donnell, MME ^{[1
]}

Sheldon, A ^{[1
]}

Tarsa, RJ ^{[1
]}

Verni, CJ ^{[1
]}

Coffen, DL ^{[1
]}

机构：

[1] ArQule Inc, Medford, MA 02155 USA

来源：

TETRAHEDRON | 1998年 / 54卷 / 16期

关键词：

D O I：

10.1016/S0040-4020(98)00134-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A procedure for the sequential, selective derivatization of cyanuric chloride that allows for the incorporation of carbohydrates and peptides has been elucidated. As a result, large combinatorial arrays of individual derivatives, over 40,000 in all, have been produced in 50 mu mole quantities using automated parallel solution phase synthesis. The use of this technology in a search for protease inhibitors, glycopeptide surrogates and other bioactive compound classes will also be discussed. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：4051 / 4065

页数：15

共 12 条

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