Secondary losses via γ-lactam formation in hot electron capture dissociation:: A missing link to complete de novo sequencing of proteins?

被引：37

作者：

Kjeldsen, F

Zubarev, R

机构：

[1] Univ So Denmark, Dept Chem, DK-5230 Odense M, Denmark

[2] Univ Uppsala, Lab Biol & Med Mass Spectrometry, Uppsala, Sweden

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 22期

关键词：

D O I：

10.1021/ja035042c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Differentiating between the isomeric isoleucine and leucine amino acid residues can be accomplished by a gas-phase fragmentation reaction in which an N-terminal radical site of a C-terminal fragment initiates formation of a five-membered ring with the β-carbon in the adjacent residue. Copyright © 2003 American Chemical Society.

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收藏

页码：6628 / 6629

页数：2

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