Transcriptional Repression in ES Cells

被引：6

作者：

Cheong, Clara Y. ^{[1
]}

Lufkin, Thomas ^{[1
]}

机构：

[1] Genome Inst Singapore, Singapore 138672, Singapore

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2010年 / 110卷 / 02期

关键词：

STEM CELLS; EPIGENETICS; TRANSCRIPTIONAL REPRESSION; METHYLATION; HISTONE MODIFICATION; EMBRYONIC STEM-CELLS; ZINC-FINGER PROTEINS; SELF-RENEWAL; REGULATORY CIRCUITRY; DEVELOPMENTAL REGULATORS; EPIGENETIC CONTROL; NUCLEAR PERIPHERY; GENE-REGULATION; FACTOR OCT-4; HISTONE H3;

D O I：

10.1002/jcb.22576

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The dynamics of embryonic stem cell pluripotency is orchestrated by an interplay of transcriptional and epigenetic regulation in a systematic and modular manner. While the ES cell stage is marked by multiple loci with bivalent chromatin marks that prepare genes for imminent activation on differentiation, this open chromatin conformation is tempered by repressive machinery that prevent premature expression of key developmental genes. This review serves to highlight key ES transcription factors and their known links to the epigenetic machinery via known protein complexes. J. Cell. Biochem. 110: 288-293, 2010. (C) 2010 Wiley-Liss, Inc.

引用

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页码：288 / 293

页数：6

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