Granulocytic ehrlichiosis in mice deficient in phagocyte oxidase or inducible nitric oxide synthase

被引：27

作者：

Banerjee, R ^{[1
]}

Anguita, J ^{[1
]}

Fikrig, E ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Internal Med, Sect Rheumatol,Lab Clin Invest 608, New Haven, CT 06520 USA

来源：

INFECTION AND IMMUNITY | 2000年 / 68卷 / 07期

关键词：

D O I：

10.1128/IAI.68.7.4361-4362.2000

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mice deficient in phox (gp91(phox-/-)) or NOS2 (NOS2(-/-)) were infected with the agent of human granulocytic ehrlichiosis (HGE) to evaluate the importance of these pathways in the eradication of HGE bacteria, NOS2(-/-) mice had delayed clearance of the HGE agent in comparison to control or gp91(phox-/-) mice, suggesting that reactive nitrogen intermediates play a role in the early control of HGE.

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页码：4361 / 4362

页数：2

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