Chromosome 1p aberrations are frequent in human primary hepatocellular carcinoma

被引：30

作者：

Chen, HL ^{[1
]}

Chen, YC ^{[1
]}

Chen, DS ^{[1
]}

机构：

[1] NATL TAIWAN UNIV HOSP,HEPATITIS RES CTR,TAIPEI,TAIWAN

来源：

CANCER GENETICS AND CYTOGENETICS | 1996年 / 86卷 / 02期

关键词：

D O I：

10.1016/0165-4608(95)00186-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To investigate the chromosomal changes in hepatocellular carcinoma in humans, metaphase chromosomes obtained directly from short-term culture of resected human primary hepato-cellular carcinoma tissues were studied in seven patients. Among the five successfully karyotyped cases, cytogenetic analysis showed highly different and complex chromosomal changes in the cancer tissue in four patients. Structural aberrations of chromosome 1 and deletion of Ip with breakpoints at p22 or p32 were the most common abnormalities, and were found in the four successfully analyzed cases. Loss of 1p may be important in hepatocarcinogenesis, and warrants further characterization by molecular genetic analysis.

引用

页码：102 / 106

页数：5

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