Selamectin: a novel broad-spectrum endectocide for dogs and cats

被引：87

作者：

Bishop, BF ^{[1
]}

Bruce, CI

Evans, NA

Goudie, AC

Gration, KAE

Gibson, SP

Pacey, MS

Perry, DA

Walshe, NDA

Witty, MJ

机构：

[1] Pfizer Ltd, Div Cent Res, Anim Hlth Discovery, Sandwich CT13 9NJ, Kent, England

[2] Pfizer Inc, Div Cent Res, Anim Hlth Discovery, Groton, CT 06340 USA

来源：

VETERINARY PARASITOLOGY | 2000年 / 91卷 / 3-4期

关键词：

selamectin; endectocide; cats; dogs; Ctenocephalides felis; Dirofilaria immitis; gastrointestinal nematodes; ticks;

D O I：

10.1016/S0304-4017(00)00289-2

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Selamectin, 25-cyclohexyl-25-de(1-methylpropyl)-5-deoxy-22,23-dihydro-5-(hydroxyimino)-avermectin B1 monosaccharide, is a novel endectocide with a unique combination of efficacy and safety in dogs and cats following both oral and topical administration. The compound is active against fleas and ticks, intestinal hookworms and ascarids, and immature heartworms. Also it is well tolerated at higher dosages than 22,23-dihydroavermectin B1a (DHAVM) or milbemycin oxime in Collies, which is a breed known to exhibit idiosyncratic sensitivity to avermectins. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：163 / 176

页数：14

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