MAO-A gene polymorphisms are associated with major depression and sleep disturbance in males

被引：50

作者：

Du, LS ^{[1
]}

Bakish, D ^{[1
]}

Ravindran, A ^{[1
]}

Hrdina, PD ^{[1
]}

机构：

[1] Univ Ottawa, Mental Hlth Res Inst, Ottawa, ON K1Z 7K4, Canada

来源：

NEUROREPORT | 2004年 / 15卷 / 13期

关键词：

clusters of depressive symptoms; haplotype analysis; insomnia; major depression; monoamine oxidase A;

D O I：

10.1097/00001756-200409150-00020

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated whether the genetic variants of the MAO-A gene were associated with major depression and/or the clusters of depressive symptoms. The EcoRV and the uVNTR polymorphisms were studied in a population of 191 patients with major depression and 233 control subjects. The EcoRV polymorphism was found to be associated with depression in males but not in females. Haplotype analysis revealed that one of the haplotypes (EcoRV2-uVNTRI) was significantly more frequent among male patients than male controls. Among the HAMD symptom clusters, insomnia scores were significantly higher in male patients carrying allele 2 of the EcoRV polymorphism. These data suggest that the EcoRV and uVNTR polymorphisms may be involved in the pathogenesis of major depression and associated with insomnia in depressed patients.

引用

页码：2097 / 2101

页数：5

共 25 条

[1]

Balciuniene J, 2002, HUM GENET, V110, P1

[2]

BENCA RM, 1992, ARCH GEN PSYCHIAT, V49, P651

[3] Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene [J].

Caspi, A ;

Sugden, K ;

Moffitt, TE ;

Taylor, A ;

Craig, IW ;

Harrington, H ;

McClay, J ;

Mill, J ;

Martin, J ;

Braithwaite, A ;

Poulton, R .

SCIENCE, 2003, 301 (5631) :386-389

[4] Role of genotype in the cycle of violence in maltreated children [J].

Caspi, A ;

McClay, J ;

Moffitt, TE ;

Mill, J ;

Martin, J ;

Craig, IW ;

Taylor, A ;

Poulton, R .

SCIENCE, 2002, 297 (5582) :851-854

[5] Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder [J].

Deckert, J ;

Catalano, M ;

Syagailo, YV ;

Bosi, M ;

Okladnova, O ;

Di Bella, D ;

Nöthen, MM ;

Maffei, P ;

Franke, P ;

Fritze, J ;

Maier, W ;

Propping, P ;

Beckmann, H ;

Bellodi, L ;

Lesch, KP .

HUMAN MOLECULAR GENETICS, 1999, 8 (04) :621-624

[6] Association between monoamine oxidase A activity in human male shin fibroblasts and genotype of the MAOA promoter-associated variable number tandem repeat [J].

Denney, RM ;

Koch, H ;

Craig, IW .

HUMAN GENETICS, 1999, 105 (06) :542-551

[7] High activity-related allele of MAO-A gene associated with depressed suicide in males [J].

Du, LS ;

Faludi, G ;

Palkovits, M ;

Sotonyi, P ;

Bakish, D ;

Hrdina, PD .

NEUROREPORT, 2002, 13 (09) :1195-1198

[8] Tryptophan hydroxylase gene 218A/C polymorphism is associated with somatic anxiety in major depressive disorder [J].

Du, LS ;

Bakish, D ;

Hrdina, PD .

JOURNAL OF AFFECTIVE DISORDERS, 2001, 65 (01) :37-44

[9]

HOTAMISLIGIL GS, 1991, AM J HUM GENET, V49, P383

[10]

Hsu YPP, 1996, AM J PSYCHIAT, V153, P1209

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