Stereotaxic rTMS for the treatment of auditory hallucinations in schizophrenia

被引：76

作者：

Schönfeldt-Lecuona, C

Grön, G

Walter, H

Büchler, N

Wunderlich, A

Spitzer, M

Herwig, U

机构：

[1] Univ Ulm, Dept Psychiat 3, D-89075 Ulm, Germany

[2] Univ Ulm, Dept Radiol, D-89075 Ulm, Germany

[3] Psychiat Univ Clin Zurich, CH-8032 Zurich, Switzerland

来源：

NEUROREPORT | 2004年 / 15卷 / 10期

关键词：

auditory verbal hallucinations; functional magnetic resonance imaging; neuronavigation; transcranial magnetic stimulation;

D O I：

10.1097/01.wnr.0000126504.89983.ec

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Auditory verbal hallucinations in schizophrenia may be due to dysfunctional inner speech-related cortical areas. Repetitive transcranial magnetic stimulation (rTMS) has been reported to be an effective treatment of hallucinations. In a cross-over sham controlled study, we guided rTMS stereotactically to inner speech-related cortical areas in hallucinating patients. These areas were identified individually prior to rTMS using fMRI in a subgroup of our patients. Active stimulation was applied over Broca's area and over the superior temporal gyrus as determined by fMRI, or according to structural images in the remaining patients. rTMS did not lead to a significant reduction of hallucination severity. Conclusively, rTMS has to be regarded critically as a possible novel tool for the treatment of hallucinations.

引用

收藏

页码：1669 / 1673

页数：5

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