Coming back to a missing immune deviation as the main explanatory mechanism for the hygiene hypothesis

被引：67

作者：

Romagnani, Sergio ^{[1
]}

机构：

[1] Univ Florence, Dept Internal Med, I-50134 Florence, Italy

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2007年 / 119卷 / 06期

关键词：

hygiene hypothesis; TLR; pathogen-associated molecular pattern; Delta-4; jagged-1; notch; IL-12; T(H)1; T(H)2; immune deviation;

D O I：

10.1016/j.jaci.2007.04.005

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

引用

页码：1511 / 1513

页数：3

共 20 条

[1] Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells [J].

Akdis, M ;

Verhagen, J ;

Taylor, A ;

Karamloo, F ;

Karagiannidis, C ;

Crameri, R ;

Thunberg, S ;

Deniz, G ;

Valenta, R ;

Fiebig, H ;

Kegel, C ;

Disch, R ;

Schmidt-Weber, CB ;

Blaser, K ;

Akdis, CA .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (11) :1567-1575

[2] Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells [J].

Amsen, D ;

Blander, JM ;

Lee, GR ;

Tanigaki, K ;

Honjo, T ;

Flavell, RA .

CELL, 2004, 117 (04) :515-526

[3] Mechanisms of disease: The effect of infections on susceptibility to autoimmune and allergic diseases [J].

Bach, JF .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (12) :911-920

[4] The novel synthetic immune response modifier R-848 (Resiquimod) shifts human allergen-specific CD4+ TH2 lymphocytes into IFN-γ-producing cells [J].

Brugnolo, F ;

Sampognaro, S ;

Liotta, F ;

Cosmi, L ;

Annunziato, F ;

Manuelli, C ;

Campi, P ;

Maggi, E ;

Romagnani, S ;

Parronchi, P .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2003, 111 (02) :380-388

[5] Acinetobacter lwoffli and Lactococcus lactis strains isolated from farm cowsheds possess strong allergy-protective properties [J].

Debarry, Jennifer ;

Garn, Holger ;

Hanuszkiewicz, Anna ;

Dickgreber, Nina ;

Bluemer, Nicole ;

von Mutius, Erika ;

Bufe, Albrecht ;

Gatermann, Soeren ;

Renz, Harald ;

Holst, Otto ;

Heine, Holger .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 119 (06) :1514-1521

[6] Redirection of allergen-specific TH2 responses by a modified adenine through Toll-like receptor 7 interaction and IL-12/IFN release [J].

Fili, Lucia ;

Ferri, Simona ;

Guarna, Francesco ;

Sampognaro, Salvatore ;

Manuelli, Cinzia ;

Liotta, Francesco ;

Cosmi, Lorenzo ;

Matucci, Andrea ;

Vultaggio, Alessandra ;

Annunziato, Francesco ;

Maggi, Enrico ;

Guarna, Antonio ;

Romagnani, Sergio ;

Parronchi, Paola .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2006, 118 (02) :511-517

[7] Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma [J].

Hawrylowicz, CM ;

O'Garra, A .

NATURE REVIEWS IMMUNOLOGY, 2005, 5 (04) :271-283

[8]

HURTADO A, 2005, KIDNEY INT S, V97, P62

[9] Is the prevalence of wheeze in children altered by neonatal BCG vaccination? [J].

Linehan, Mary F. ;

Frank, Timothy L. ;

Hazell, Michelle L. ;

Francis, Helen C. ;

Morris, Julie A. ;

Baxter, David N. ;

Niven, Robert M. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 119 (05) :1079-1085

[10] Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease [J].

Ling, EM ;

Smith, T ;

Nguyen, XD ;

Pridgeon, C ;

Dallman, M ;

Arbery, J ;

Carr, VA ;

Robinson, DS .

LANCET, 2004, 363 (9409) :608-615

← 1 2 →