Measurement of cerebral circulation by dynamic susceptibility contrast-enhanced MRI: effect of tracer delay

被引:3
作者
Ibaraki, M [1 ]
Shimosegawa, E [1 ]
Toyoshima, H [1 ]
Ishigame, K [1 ]
Miura, S [1 ]
Takahashi, K [1 ]
Kanno, I [1 ]
机构
[1] Akita Res Inst Brain & Blood Vessels, Dept Radiol & Nucl Med, Akita 0100874, Japan
来源
QUANTITATION IN BIOMEDICAL IMAGING WITH PET AND MRI | 2004年 / 1265期
关键词
cerebral blood flow; dynamic susceptibility contrast-enhanced magnetic resonance imaging; tracer delay; singular value decomposition; deconvolution;
D O I
10.1016/j.ics.2004.04.009
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Cerebral blood flow (CBF) and mean transit time (MTT) can be determined by dynamic susceptibility contrast-enhanced magnetic resonance imaging (DSC-MRI) and deconvolution with an arterial input function (AIF). However, deconvolution with a singular value decomposition (SVD) method is sensitive to the tracer delay that often occurs in patients with cerebrovascular disease. We developed a delay correction method that determines tracer delay by means of least-squares fitting pixel-by-pixel. The corrected CBF was determined by SVD deconvolution after time-shifting of the measured concentration curve. The simulations showed that the corrected CBF was insensitive to tracer delay irrespective of the vascular model, although CBF fluctuation increased slightly. We applied the delay correction to the CBF and MTT images acquired for a patient with hyperacute stroke and unilateral occlusion of the middle cerebral artery. The delay correction modulated the contrast of perfusion images. For hyperacute stroke patients, tracer delay correction is essential to obtain reliable CBF and MTT images when SVD deconvolution is used. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码:159 / 166
页数:8
相关论文
共 12 条
[1]   Magnetic resonance imaging of acute stroke [J].
Baird, AE ;
Warach, S .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1998, 18 (06) :583-609
[2]  
Calamante F, 2000, MAGN RESON MED, V44, P466, DOI 10.1002/1522-2594(200009)44:3<466::AID-MRM18>3.0.CO
[3]  
2-M
[4]   A DECONVOLUTION METHOD FOR EVALUATING INDICATOR-DILUTION CURVES [J].
GOBBEL, GT ;
FIKE, JR .
PHYSICS IN MEDICINE AND BIOLOGY, 1994, 39 (11) :1833-1854
[5]   ON THE THEORY OF THE INDICATOR-DILUTION METHOD FOR MEASUREMENT OF BLOOD FLOW AND VOLUME [J].
MEIER, P ;
ZIERLER, KL .
JOURNAL OF APPLIED PHYSIOLOGY, 1954, 6 (12) :731-744
[6]   High resolution measurement of cerebral blood flow using intravascular tracer bolus passages .2. Experimental comparison and preliminary results. [J].
Ostergaard, L ;
Sorensen, AG ;
Kwong, KK ;
Weisskoff, RM ;
Gyldensted, C ;
Rosen, BR .
MAGNETIC RESONANCE IN MEDICINE, 1996, 36 (05) :726-736
[7]   High resolution measurement of cerebral blood flow using intravascular tracer bolus passages .1. Mathematical approach and statistical analysis [J].
Ostergaard, L ;
Weisskoff, RM ;
Chesler, DA ;
Gyldensted, C ;
Rosen, BR .
MAGNETIC RESONANCE IN MEDICINE, 1996, 36 (05) :715-725
[8]   QUANTIFICATION OF REGIONAL CEREBRAL BLOOD-FLOW AND VOLUME WITH DYNAMIC SUSCEPTIBILITY CONTRAST-ENHANCED MR-IMAGING [J].
REMPP, KA ;
BRIX, G ;
WENZ, F ;
BECKER, CR ;
GUCKEL, F ;
LORENZ, WJ .
RADIOLOGY, 1994, 193 (03) :637-641
[9]   Signal-to-noise ratio effects in quantitative cerebral perfusion using dynamic susceptibility contrast agents [J].
Smith, MR ;
Lu, H ;
Frayne, R .
MAGNETIC RESONANCE IN MEDICINE, 2003, 49 (01) :122-128
[10]   Hyperacute stroke: Simultaneous measurement of relative cerebral blood volume, relative cerebral blood flow, and mean tissue transit time [J].
Sorensen, AG ;
Copen, WA ;
Ostergaard, L ;
Buonanno, FS ;
Gonzalez, RG ;
Rordorf, G ;
Rosen, BR ;
Schwamm, LH ;
Weisskoff, RM ;
Koroshetz, WJ .
RADIOLOGY, 1999, 210 (02) :519-527