A Highly Selective, Polymer-Supported Organocatalyst for Michael Additions with Enzyme-Like Behavior

被引：99

作者：

Alza, Esther ^{[1
]}

Pericas, Miquel A. ^{[1
,2
]}

机构：

[1] Inst Chem Res Catalonia ICIQ, Tarragona 43007, Spain

[2] Univ Barcelona, Dept Quim Organ, E-08028 Barcelona, Spain

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2009年 / 351卷 / 18期

关键词：

asymmetric catalysis; Michael addition; nitroolefins; organocatalysis; synthetic enzymes; ENANTIOSELECTIVE MICHAEL; BETA-NITROSTYRENES; ALPHA; ALPHA-DISUBSTITUTED ALDEHYDES; ASYMMETRIC ORGANOCATALYSTS; PYRROLIDINE SULFONAMIDE; 1,4-ADDITION REACTIONS; CONJUGATE ADDITION; CLICK CHEMISTRY; CHIRAL AMINES; SILYL ETHER;

D O I：

10.1002/adsc.200900817

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A polymer-supported alpha,alpha-diarylprolinol silyl ether displays catalytic activity and enantioselectivity comparable to the best homogeneous catalysts in the Michael addition of aldehydes to nitro-olefins. Above all, the combination of polymer backbone, triazole linker, and catalytic unit confers to it an unprecedented substrate selectivity in favor of linear, short-chain aldehydes.

引用

页码：3051 / 3056

页数：6

共 71 条

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