Model based conjectures on mammalian clock controversies

被引:22
作者
Forger, DB
Peskin, CS
机构
[1] NYU, Courant Inst Math Sci, New York, NY 10012 USA
[2] NYU, Ctr Neural Sci, New York, NY 10012 USA
关键词
circadian clock; mathematical models; eukaryotic transcription regulation; PER; CRY; CLOCK; BMAL Rev-erb alpha; phase response curve;
D O I
10.1016/j.jtbi.2004.04.041
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
We explore some predictions of a previously developed detailed model of molecular timekeeping in mammals (Forger and Peskin, PNAS, 100: 14806) in areas where our understanding of clock mechanisms are incomplete. It is conjectured that: (1) the clock's 24-h period depends on mRNA stability. (2) REV-ERBalpha suppresses and/or entrains rhythms in peripheral tissues by regulating CRY1 transcription. (3) CLK:BMAL1 oscillations are suppressed in the suprachiasmatic nuclei to enhance oscillations in other proteins. (4) PER2 is ineffective at causing phase advances because it is not induced by light during the late night. (5) The clock is a limit cycle oscillator that shows characteristics of the Evening and Morning oscillator model. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:533 / 539
页数:7
相关论文
共 22 条
[1]   mPer1 and mPer2 are essential for normal resetting of the circadian clock [J].
Albrecht, U ;
Zheng, BH ;
Larkin, D ;
Sun, ZS ;
Lee, CC .
JOURNAL OF BIOLOGICAL RHYTHMS, 2001, 16 (02) :100-104
[2]   Assembling a clock for all seasons:: Are there M and E oscillators in the genes? [J].
Daan, S ;
Albrecht, U ;
van der Horst, GTJ ;
Illnerová, H ;
Roenneberg, T ;
Wehr, TA ;
Schwartz, WJ .
JOURNAL OF BIOLOGICAL RHYTHMS, 2001, 16 (02) :105-116
[3]   A neuronal ryanodine receptor mediates light-induced phase delays of the circadian clock [J].
Ding, JM ;
Buchanan, GF ;
Tischkau, SA ;
Chen, D ;
Kuriashkina, L ;
Faiman, LE ;
Alster, JM ;
McPherson, PS ;
Campbell, KP ;
Gillette, MU .
NATURE, 1998, 394 (6691) :381-384
[4]   Rhythmic histone acetylation underlies transcription in the mammalian circadian clock [J].
Etchegaray, JP ;
Lee, C ;
Wade, PA ;
Reppert, SM .
NATURE, 2003, 421 (6919) :177-182
[5]   Analysis of clock proteins in mouse SCN demonstrates phylogenetic divergence of the circadian clockwork and resetting mechanisms [J].
Field, MD ;
Maywood, ES ;
O'Brien, JA ;
Weaver, DR ;
Reppert, SM ;
Hastings, MH .
NEURON, 2000, 25 (02) :437-447
[6]   A detailed predictive model of the mammalian circadian clock [J].
Forger, DB ;
Peskin, CS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (25) :14806-14811
[7]   Reconciling mathematical models of biological clocks by averaging on approximate manifolds [J].
Forger, DB ;
Kronauer, RE .
SIAM JOURNAL ON APPLIED MATHEMATICS, 2002, 62 (04) :1281-1296
[8]   A simpler model of the human circadian pacemaker [J].
Forger, DB ;
Jewett, ME ;
Kronauer, RE .
JOURNAL OF BIOLOGICAL RHYTHMS, 1999, 14 (06) :532-537
[9]   Circadian periods of single suprachiasmatic neurons in rats [J].
Honma, S ;
Shirakawa, T ;
Katsuno, Y ;
Namihira, M ;
Honma, K .
NEUROSCIENCE LETTERS, 1998, 250 (03) :157-160
[10]   Posttranslational mechanisms regulate the mammalian circadian clock [J].
Lee, C ;
Etchegaray, JP ;
Cagampang, FRA ;
Loudon, ASI ;
Reppert, SM .
CELL, 2001, 107 (07) :855-867