A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

被引：3586

作者：

Frayling, Timothy M.

Timpson, Nicholas J.

Weedon, Michael N.

Zeggini, Eleftheria

Freathy, Rachel M.

Lindgren, Cecilia M.

Perry, John R. B.

Elliott, Katherine S.

Lango, Hana

Rayner, Nigel W.

Shields, Beverley

Harries, Lorna W.

Barrett, Jeffrey C.

Ellard, Sian

Groves, Christopher J.

Knight, Bridget

Patch, Ann-Marie

Ness, Andrew R.

Ebrahim, Shah

Lawlor, Debbie A.

Ring, Susan M.

Ben-Shlomo, Yoav

Jarvelin, Marjo-Riitta

Sovio, Ulla

Bennett, Amanda J.

Melzer, David

Ferrucci, Luigi

Loos, Ruth J. F.

Barroso, Ines

Wareham, Nicholas J.

Karpe, Fredrik

Owen, Katharine R.

Cardon, Lon R.

Walker, Mark

Hitman, Graham A.

Palmer, Colin N. A.

Doney, Alex S. F.

Morris, Andrew D.

Smith, George Davey

Hattersley, Andrew T.

McCarthy, Mark I.

机构：

[1] Peninsula Med Sch, Inst Biomed & Clin Sci, Exeter, Devon, England

[2] Univ Oxford, Wellcome Trust, Ctr Human Genet, Oxford, England

[3] Univ Bristol, MRC, Ctr Casual Anal Translat Epidemiol, Bristol, Avon, England

[4] Univ Oxford, Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England

[5] Royal Devon & Exeter Natl Hlth Serv Fdn Trust, Mol Genet Lab, Exeter, Devon, England

[6] Univ Bristol, Dept Oral & Dent Sci, Sch Dent, Bristol, Avon, England

[7] London Sch Hyg & Trop Med, Dept Epidemiol & Populat Hlth, London WC1, England

[8] Univ Bristol, Dept Social Med, Bristol, Avon, England

[9] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Publ Hlth, London W2 1PG, England

[10] Univ Oulu, Dept Publ Hlth Sci & Gen Practice, FIN-90014 Oulu, Finland

[11] Peninsula Med Sch, Epidemiol & Publ Hlth Grp, Exeter, Devon, England

[12] NIA, Lonitudinal Studies Sect, Clin Res Branch, NIH, Baltimore, MD 21224 USA

[13] Strangeways Res Labs, MRC, Epidemiol Unit, Cambridge, England

[14] Sanger Inst, Metab Dis Grp, Wellcome Trust, Cambridge, England

[15] Univ Newcastle, Diabet Res Grp, Sch Clin Med Sci, Newcastle Upon Tyne, Tyne & Wear, England

[16] Barts & London Royal London Hosp, Dept Diabet & Metab Med, London, England

[17] Univ Dundee, Populat Pharmacogenet Grp, Ninewells Hosp & Med Sch, Biomed Res Ctr, Dundee DD1 9SY, Scotland

[18] Univ Dundee, Ninewells Hosp & Med Sch, Diabet Res Grp, Div Med & Therapeut,Sch Med, Dundee DD1 9SY, Scotland

来源：

SCIENCE | 2007年 / 316卷 / 5826期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1126/science.1141634

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetes-susceptibility genes identified a common variant in the FTO ( fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI). An additive association of the variant with BMI was replicated in 13 cohorts with 38,759 participants. The 16% of adults who are homozygous for the risk allele weighed about 3 kilograms more and had 1.67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass.

引用

页码：889 / 894

页数：6

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