Plasticity of excitatory synaptic transmission in the spinal cord dorsal horn

被引:42
作者
Randic, M
机构
[1] Department of Veterinary Physiology and Pharmacology, Iowa State Uniuersity, Ames
来源
POLYMODAL RECEPTOR - A GATEWAY TO PATHOLOGICAL PAIN | 1996年 / 113卷
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
D O I
10.1016/S0079-6123(08)61104-8
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
This chapter focuses on the recent information derived from experiments done in vitro using spinal slice preparation and acutely isolated spinal dorsal horn (DH) neurons of young rats. The emphasis is placed on modulation of synaptic and excitatory amino acids (EAAs) responses of DH neurons by κ-opioid receptor-preferring ligands and their potential role in long-term changes in synaptic transmission related to pain. To understand how opioids produce these changes, the cellular mechanisms of opioid actions have to be known. There is increasing evidence for involvement of opioids in long lasting activity-dependent changes in the efficacy of synaptic transmission in the brain and spinal cord. Studies of long-term potentiation (LTP) implicate opioid peptides in the induction of LTP in the hippocampus. In contrast, two reports suggest that dynorphin may reduce LTP in the hippocampus in a naloxone-reversible manner, at least in part, by a presynaptic action. Understanding the cellular mechanisms underlying the κ1-agonist actions has implications both for the understanding of somatosensory processing in the spinal DH and for the development of novel analgesic strategies to prevent post-injury pain hypersensitivity. © 1996 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:463 / 506
页数:44
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