Myostatin and its implications on animal breeding:: a review

被引:140
作者
Bellinge, RHS
Liberles, DA
Iaschi, SPA
O'Brien, PA
Tay, GK [1 ]
机构
[1] Univ Western Australia, Dept Pathol, Nedlands, WA 6907, Australia
[2] Murdoch Univ, Sch Biol Sci & Biotechnol, Murdoch, WA 6150, Australia
[3] Concept Fertil Ctr, Subiaco, WA 6008, Australia
[4] Univ Bergen, Bergen Ctr Computat Sci, Computat Biol Unit, N-5020 Bergen, Norway
[5] AgriBIOTECH Pty Ltd, Claremont, WA 6010, Australia
关键词
Belgian Blue; carcass traits; double muscling; growth and differentiation factor 8; myostatin;
D O I
10.1111/j.1365-2052.2004.01229.x
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
Myostatin, or growth and differentiation factor 8 (GDF8), has been identified as the factor causing a phenotype known as double muscling, in which a series of mutations render the gene inactive, and therefore, unable to regulate muscle fibre deposition. This phenotype occurs at a high frequency in some breeds of cattle such as Belgian Blue and Peidmontese. Phylogenetic analysis has shown that there has been positive selection pressure for non-synonymous mutations within the myostatin gene family, around the time of the divergence of cattle, sheep and goats, and these positive selective pressures on non-ancestral myostatin are relatively recent. To date, there have been reports of nine mutations in coding regions of myostatin that cause non-synonymous changes, of which three cause missense mutations, including two in exon 1 and one in exon 2. The remaining six mutations, located in exons 2 and 3, result in premature stop codons, which are the mutations responsible for the double-muscling phenotype. Unfortunately, breed management problems exist for double-muscled cattle, such as birthing difficulties, which can be overcome through genetically controlled breeding programmes, as shown in this review.
引用
收藏
页码:1 / 6
页数:6
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