THE 6-MINUTE WALK TEST AS A NEW OUTCOME MEASURE IN DUCHENNE MUSCULAR DYSTROPHY

被引：297

作者：

McDonald, Craig M. ^{[1
]}

Henricson, Erik K. ^{[1
]}

Han, Jay J. ^{[1
]}

Abresch, R. Ted ^{[1
]}

Nicorici, Alina ^{[1
]}

Elfring, Gary L. ^{[2
]}

Atkinson, Leone ^{[2
]}

Reha, Allen ^{[2
]}

Hirawat, Samit ^{[2
]}

Miller, Langdon L. ^{[2
]}

机构：

[1] Univ Calif Davis, Sch Med, Dept Phys Med & Rehabil, Sacramento, CA 95817 USA

[2] PTC Therapeut, S Plainfield, NJ 07080 USA

来源：

MUSCLE & NERVE | 2010年 / 41卷 / 04期

关键词：

6-minute walk test; muscular dystrophy; Duchenne; child; case-control study; gait disorder; neurologic; ENZYME REPLACEMENT THERAPY; PHYSICAL-ACTIVITY; CORTICOSTEROID TREATMENT; DOUBLE-BLIND; DISEASE; CHILDREN; RELIABILITY; PREDNISONE; HEALTH; ALPHA;

D O I：

10.1002/mus.21544

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Walking abnormalities are prominent in Duchenne muscular dystrophy (DMD). We modified the 6-minute walk test (6MWT) for use as an outcome measure in patients with DMD and evaluated its performance in 21 ambulatory boys with DMD and 34 healthy boys, ages 4 to 12 years. Boys with DMD were tested twice, similar to 1 week apart; controls were tested once. The groups had similar age, height, and weight. All tests were completed. Boys who fell recovered rapidly from falls without injury. Mean +/- SD [range] 6-minute walk distance (6MWD) was lower in boys with DMD than in controls (366 +/- 83 [125-481] m vs. 621 +/- 68 [479-754] m; P < 0.0001; unpaired t-test). Test-retest correlation for boys with DMD was high (r = 0.91). Stride length (R-2 = 0.89; P < 0.0001) was the major determinant of 6MWD for both boys with DMD and controls. A modified 6MWT is feasible and safe, documents disease-related limitations on ambulation, is reproducible, and offers a new outcome measure for DMD natural history and therapeutic trials. Muscle Nerve 41: 500-510, 2010

引用

页码：500 / 510

页数：11

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