CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock

被引：355

作者：

DeBruyne, Jason P. ^{[1
]}

Weaver, David R. ^{[1
]}

Reppert, Steven M. ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Neurobiol, Worcester, MA 01605 USA

来源：

NATURE NEUROSCIENCE | 2007年 / 10卷 / 05期

关键词：

D O I：

10.1038/nn1884

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Heterodimers of CLOCK and BMAL1, bHLH-PAS transcription factors, are believed to be the major transcriptional regulators of the circadian clock mechanism in mammals. However, a recent study shows that CLOCK-deficient mice continue to exhibit robust behavioral and molecular rhythms. Here we report that the transcription factor NPAS2 ( MOP4) is able to functionally substitute for CLOCK in the master brain clock in mice to regulate circadian rhythmicity.

引用

页码：543 / 545

页数：3

共 13 条

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