Production of butyrolactone autoregulators by Streptomyces coelicolor A3(2)

被引:13
作者
Kawabuchi, M [1 ]
Hara, Y [1 ]
Nihira, T [1 ]
Yamada, Y [1 ]
机构
[1] Osaka Univ, Grad Sch Engn, Dept Biotechnol, Osaka 565, Japan
基金
日本学术振兴会;
关键词
butyrolactone autoregulator; Streptomyces coelicolor A3(2); aerial mycelium formation;
D O I
10.1016/S0378-1097(97)00457-6
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
We report here that Streptomyces coelicolor A3(2) produces at least seven butyrolactone autoregulators: two of the IM-2 type, four virginiae butanolide type, and one A-factor type. The most abundant one corresponds to virginiae butanolide-C-9 having a C2 side chain of nine carbons. Model butyrolactone compounds as well as extracts of S. coelicolor mycelia showed clear induction of morphological differentiation, implying that S. coelicolor A3(2) probably possessed butyrolactone-type autoregulator(s) controlling the morphological differentiation.
引用
收藏
页码:81 / 85
页数:5
相关论文
共 21 条
[1]   INDUCERS OF BOTH CYTODIFFERENTIATION AND ANTHRACYCLINE BIOSYNTHESIS OF STREPTOMYCES-GRISEUS AND THEIR OCCURRENCE IN ACTINOMYCETES AND OTHER MICROORGANISMS [J].
ERITT, I ;
GRAFE, U ;
FLECK, WF .
ZEITSCHRIFT FUR ALLGEMEINE MIKROBIOLOGIE, 1984, 24 (01) :3-12
[2]   INTERSPECIFIC INDUCERS OF CYTODIFFERENTIATION AND ANTHRACYCLINE BIOSYNTHESIS FROM STREPTOMYCES-BIKINENSIS AND STREPTOMYCES-CYANEOFUSCATUS [J].
GRAFE, U ;
REINHARDT, G ;
SCHADE, W ;
ERITT, I ;
FLECK, WF ;
RADICS, L .
BIOTECHNOLOGY LETTERS, 1983, 5 (09) :591-596
[3]  
GRAFE U, 1982, J ANTIBIOT, V35, P349
[4]   MUTANTS BLOCKED IN STREPTOMYCIN PRODUCTION IN STREPTOMYCES-GRISEUS - THE ROLE OF A-FACTOR [J].
HARA, O ;
BEPPU, T .
JOURNAL OF ANTIBIOTICS, 1982, 35 (03) :349-358
[5]  
HARA O, 1983, J GEN MICROBIOL, V129, P2939
[6]   DISTRIBUTION OF VIRGINIAE BUTANOLIDES AND IM-2 IN THE GENUS STREPTOMYCES [J].
HASHIMOTO, K ;
NIHIRA, T ;
YAMADA, Y .
JOURNAL OF FERMENTATION AND BIOENGINEERING, 1992, 73 (01) :61-65
[7]  
Hopwood D.A., 1985, GENETIC MANIPULATION
[8]   THE LEEUWENHOEK LECTURE, 1987 - TOWARDS AN UNDERSTANDING OF GENE SWITCHING IN STREPTOMYCES, THE BASIS OF SPORULATION AND ANTIBIOTIC PRODUCTION [J].
HOPWOOD, DA .
PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1988, 235 (1279) :121-+
[9]   UNSTABLE GENETIC DETERMINANT OF A-FACTOR BIOSYNTHESIS IN STREPTOMYCIN-PRODUCING ORGANISMS - CLONING AND CHARACTERIZATION [J].
HORINOUCHI, S ;
KUMADA, Y ;
BEPPU, T .
JOURNAL OF BACTERIOLOGY, 1984, 158 (02) :481-487
[10]  
KLEINER EM, 1976, BIOORG KHIM+, V2, P1142